Journal ArticleDOI
Warfarin Genotyping Reduces Hospitalization Rates: Results From the MM-WES (Medco-Mayo Warfarin Effectiveness Study)
About:
This article is published in Yearbook of Oncology.The article was published on 2010-01-01. It has received 102 citations till now. The article focuses on the topics: Warfarin.read more
Citations
More filters
Journal ArticleDOI
Genomics and Drug Response
TL;DR: This article reviews recent pharmacogenetic and pharmacogenomic advances and discusses how such advances are reflected in the labeling of drugs.
Journal ArticleDOI
Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects
TL;DR: The pharmacogenomics of DMEs is reviewed, with particular emphasis on novelties, and it is concluded that recent studies have emphasized the importance of CYP2C19 polymorphism for the effects of clopidogrel, whereas the CYP1A2 polymorphism appears to have a role in anticoagulant treatment, although inferior to VKORC1.
Journal ArticleDOI
Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial.
Brian F. Gage,Anne R. Bass,H. Lin,H. Lin,Scott C. Woller,Scott C. Woller,Scott M. Stevens,Scott M. Stevens,Noor Al-Hammadi,Juan Li,Tomás Rodriguez,J. Philip Miller,Gwendolyn A. McMillin,Robert C. Pendleton,Amir K. Jaffer,Cristi R. King,Brandi De Vore Whipple,Rhonda Porche-Sorbet,Lynnae Napoli,Kerri Merritt,Anna M. Thompson,Anna M. Thompson,Gina Hyun,Gina Hyun,Jeffrey L. Anderson,Jeffrey L. Anderson,Wesley Hollomon,Robert L. Barrack,Ryan M. Nunley,Gerard Moskowitz,Victor G. Davila-Roman,Charles S. Eby +31 more
TL;DR: Among patients undergoing elective hip or knee arthroplasty and treated with perioperativewarfarin, genotype-guided warfarin dosing compared with clinically guided dosing reduced the combined risk of major bleeding, INR of 4 or greater, venous thromboembolism, or death.
Journal ArticleDOI
Genetic Warfarin Dosing: Tables Versus Algorithms
TL;DR: Although genetic tables predicted warfarin dose better than empiric dosing, formal pharmacogenetic algorithms were the most accurate.
Journal ArticleDOI
Pulmonary embolism: risk assessment and management
TL;DR: Current advances in oral anticoagulation with vitamin K antagonists, and with new direct inhibitors of factor Xa and thrombin, which may contribute to profound changes in the treatment and secondary prophylaxis of venous thrombo-embolism in the near future are discussed.
References
More filters
Journal ArticleDOI
Warfarin Genotyping Reduces Hospitalization Rates: Results From the MM-WES (Medco-Mayo Warfarin Effectiveness Study)
Robert S. Epstein,Thomas P. Moyer,Ronald E. Aubert,Dennis J. O'Kane,Fang Xia,Robert R. Verbrugge,Brian F. Gage,J. Russell Teagarden +7 more
TL;DR: Warfarin genotyping reduced the risk of hospitalization in outpatients initiating warfarin treatment, and the Clinical and Economic Impact of Pharmacogenomic Testing of Warfarin Therapy in Typical Community Practice Settings was evaluated.