Journal ArticleDOI
WNT5A promotes migration and invasion of human osteosarcoma cells via SRC/ERK/MMP-14 pathway.
TLDR
Results indicate that WNT5A activates SRC/ERK1/2 signal pathway, leading to the upregulation of MMP‐14 expression and MG‐63 cells migration and invasion.About:
This article is published in Cell Biology International.The article was published on 2018-05-01. It has received 21 citations till now. The article focuses on the topics: Proto-oncogene tyrosine-protein kinase Src & Wnt signaling pathway.read more
Citations
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Journal ArticleDOI
Wnt signaling and Loxl2 promote aggressive osteosarcoma
Kazuhiko Matsuoka,Latifa Bakiri,Lena I. Wolff,Markus Linder,Amanda Mikels-Vigdal,Ana Patiño-García,Fernando Lecanda,Christine Hartmann,Maria Sibilia,Erwin F. Wagner +9 more
TL;DR: It is demonstrated that Wnt signaling promotes c-Fos-induced OS formation via the actions of the collagen-modifying enzyme Loxl2, and therapeutic targeting of Wnt and/or LoxL2 should be considered to potentiate the inadequate current treatments for pediatric, recurrent, and metastatic OS.
Journal ArticleDOI
PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization.
Meng-Yen Li,Wen-Hsin Peng,Chien-Hsun Wu,Ya-Min Chang,Yu Ling Lin,Geen-Dong Chang,Han-Chung Wu,Guang-Chao Chen,Guang-Chao Chen +8 more
TL;DR: Depletion of the FERM and PDZ domain-containing protein tyrosine phosphatase PTPN3 enhances lung cancer cell migration/invasion and metastasis by promoting actin filament assembly and focal adhesion dynamics.
Journal ArticleDOI
WNT5B in Physiology and Disease.
Sarocha Suthon,Rachel S. Perkins,Vitezslav Bryja,Vitezslav Bryja,Gustavo A. Miranda-Carboni,Susan A. Krum +5 more
TL;DR: WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types.
Journal ArticleDOI
DCLK1 Plays a Metastatic-Promoting Role in Human Breast Cancer Cells.
Heshu Liu,Tao Wen,Ying Zhou,Xiaona Fan,Tan Du,Tianbo Gao,Lina Li,Jian Liu,Lei Yang,Jiannan Yao,Yang Ge,Guangyu An +11 more
TL;DR: It was shown that, compared with the corresponding control cells, DCLK1 overexpression led to an increase in metastatic behaviors including enhanced migration and invasion of T47D cells, further supporting a metastatic-promoting role for D CLK1.
Journal ArticleDOI
Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism.
TL;DR: It is demonstrated that Wnt5a can induce activation of ERK1/2 and enhance CLL-cell proliferation via a ROR1/DOCK2-dependent pathway independent of BTK.
References
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Journal ArticleDOI
Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols
Stefan S. Bielack,Beate Kempf-Bielack,Günter Delling,G. Ulrich Exner,Silke Flege,Knut Helmke,Rainer Kotz,Mechthild Salzer-Kuntschik,M. Werner,Winfried Winkelmann,Andreas Zoubek,Heribert Jürgens,Kurt Winkler +12 more
TL;DR: Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis.
Book ChapterDOI
The Epidemiology of Osteosarcoma
Giulia Ottaviani,Norman Jaffe +1 more
TL;DR: The overall 5-year survival rate for osteosarcoma is 68%, without significant gender difference, and the age of the patient is correlated with the survival, with the poorest survival among older patients.
Journal ArticleDOI
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
Amanda J. Mikels,Roel Nusse +1 more
TL;DR: This study shows for the first time that a single Wnt ligand can initiate discrete signaling pathways through the activation of two distinct receptors, and proposes a model wherein receptor context dictates Wnt signaling output.
Journal ArticleDOI
Adhesion signaling - crosstalk between integrins, Src and Rho.
TL;DR: This Commentary discusses recent advances in the understanding of the dynamic regulation of the molecular connections between integrins, Src-family kinases and Rho-family GTPases and how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease.
Journal ArticleDOI
The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation
TL;DR: The nuclear translocation of signaling components may emerge as an important regulatory layer in the induction of cellular processes, and therefore, may serve as targets for therapeutic intervention in signaling-related diseases such as cancer and diabetes.