Showing papers in "Pancreatology in 2013"

TL;DR: The 2012 IAP/APA guidelines provide recommendations concerning key aspects of medical and surgical management of acute pancreatitis based on the currently available evidence that should serve as a reference standard for current management and guide future clinical research on acute Pancreatitis.

TL;DR: Fine-needle aspiration has moderate sensitivity but high specificity for mucinous lesions and EUS-FNA, when used in conjunction with cross sectional imaging, is a useful diagnostic tool for the correct identification of mucinous cysts.

TL;DR: Any patient with chronic pancreatitis should be monitored for development of diabetes, those with long-standing duration of disease, prior partial pancreatectomy, and early onset of calcific disease may be at higher risk.

TL;DR: Deficiencies of fat-soluble vitamins and a decreased BMD are frequently present in chronic pancreatitis, even in exocrine sufficient patients, and all patients with chronic Pancreatitis should be routinely screened for fat- soluble vitamin deficiencies and a decreases BMD.

TL;DR: EUS-FNA has the high sensitivity and specificity in differentiating pancreatic cancer and is also a safe diagnostic modality with little complications, indicating a good performance of overall accuracy.

TL;DR: In operated patients, steatorrhea may be present even if FE-1 is only slightly reduced, that suggests a role for non pancreatic factors, and FE1 is not useful to identify operated patients at risk of malabsorption.

TL;DR: CT is a good quality initial investigation to be used in conjunction with clinical data and MRCP can add useful information regarding MPD communication but should be used judiciously.

TL;DR: Long term indwelling transmural stents in patients with WOPN and DPDS seem to be safe and also appear to decrease the risk of PFC recurrence.

TL;DR: Recommendations were given regarding the management of pain, pseudocysts, duodenal and biliary stenosis, pancreatic fistula and ascites, left portal hypertension, diabetes mellitus, exocrine pancreatic insufficiency, and nutritional support in CP.

TL;DR: The systemic review showed that the randomized controlled trials comparing different analgesics were of low quality and did not favor clearly any particular analgesic for pain relief in acute pancreatitis.

TL;DR: The findings support the feasibility and safety of ERP-PD and improved patients' outcomes, significant bed day savings and increase National Health Service productivity are anticipated with implementation of ERp-PD on a larger scale.

TL;DR: It is now increasingly evident that research targeted towards the interactions between these cell types, ideally at an early stage of tumor development, is imperative in order to propel the way forward to more effective treatments.

TL;DR: PSCs should now be recognized as not only profibrogenic cells but as multi-functional cells in the pancreas.

TL;DR: Electroacupuncture was an effective treatment for relieving pancreatic cancer pain and follow-up found a significant reduction in pain intensity in the electroacupuncture group compared with the control group.

TL;DR: This meta-analysis demonstrates a clear advantage for glutamine supplementation in patients with acute pancreatitis who receive total parenteral nutrition and who receive enteral nutrition in combination with other immunonutrients.

TL;DR: Evolution of practice and perioperative management of PD for pancreatic cancer at a tertiary cancer center in India improvedPerioperative outcomes and helped sustain the improvements despite increasing surgical volume, as well as reducing overall morbidity rates.

TL;DR: In patients with PEI due to CP, treatment with pancreatin for one year was associated with significant improvements in fat absorption, nitrogen absorption, and nutritional parameters, improvements in clinical symptoms, and a favorable safety and tolerability profile.

TL;DR: The association between pancreatic density and PF is a novel finding and consideration of duct width as a continuous variable using pre-operative CT imaging can be used to simply predict risk of PF.

TL;DR: HBV/HCV infection may represent a risk factor for PAC, but the small number of available researches, involving mainly populations of Asian ethnicity and the substantial variation between different geographical areas in seroprevalence are limiting factors to present meta-analysis.

TL;DR: This quid pro quo of tumour cells and M2-macrophages could serve as a new target for future immunotherapies that interrupt tumour promoting activities of TAMs and change the iNOS-arginase balance towards their tumoricidal capacities.

TL;DR: It is demonstrated that miR-181b was associated with the resistance of pancreatic cancer cells to gemcitabine, and verified that miCYLD enhances the activity of NF-κB by inhibiting CYLD, leading to the resistance to gem citabine.

TL;DR: An overview of the recent advances in the field of laparoscopic left pancreatectomy (LLP) is provided and potential future developments are discussed.

TL;DR: This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis.

TL;DR: Results indicate that Sal could influence the cell growth and migration in pancreatic cancer cells in vitro, which may occur by inhibition of Wnt/β-catenin signaling.

TL;DR: The Spanish Pancreatic Club has developed a consensus on the management of CP, and this first part of the consensus addresses the diagnosis of CP and its complications.

TL;DR: In the European population, the binding pancreaticojejunostomy according to Peng did not preclude or reduce the postoperative pancreatic fistula rate.

TL;DR: The results implied that NAM might be a potential therapeutic agent for human pancreatic cancer treatment through downregulating SIRT1, K-Ras and P-Akt expression.

TL;DR: EPI in patients with diabetes mellitus occurred less frequently than in previous studies, probably due to the strict exclusion criteria (age, alcohol intake).

TL;DR: In a few patients with IPMNs, IgG4-positive plasma cell infiltration can occur in the peritumorous area and the association of an IPMN with AIP type 1-like changes seems to be exceptional and coincidental.