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World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects
Christiane,Druml,Wolzt,Pleiner +3 more
- Iss: 3, pp 235-237
TLDR
Adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964, and amended by the 29th WMAs, Tokyo, Japan, October 1975, and the 52nd WMAGeneral Assembly, Edinburgh, Scotland, October 2000.Abstract:
Adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964; amended by the 29th WMA General Assembly, Tokyo, Japan, October 1975; 35th WMA General Assembly, Venice, Italy, October 1983; 41st WMA General Assembly, Hong Kong, September 1989; 48th WMA General Assembly, Somerset West, Republic of South Africa, October 1996, and the 52nd WMA General Assembly, Edinburgh, Scotland, October 2000.read more
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Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
TL;DR: The response to placebo in published trials of antidepressant medication for MDD is highly variable and often substantial and has increased significantly in recent years, as has the response to medication.
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Effect of time spent outdoors at school on the development of myopia among children in China a randomized clinical trial
Mingguang He,Fan Xiang,Yangfa Zeng,Jincheng Mai,Qianyun Chen,Jian Zhang,Wayne Smith,Kathryn A. Rose,Ian G. Morgan +8 more
TL;DR: Among 6-year-old children in Guangzhou, China, the addition of 40 minutes of outdoor activity at school compared with usual activity resulted in a reduced incidence rate of myopia over the next 3 years, and the efficacy of increasing time spent outdoors at school in preventing incident myopia was assessed.
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Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia
John F. Seymour,Thomas J. Kipps,Barbara Eichhorst,Peter Hillmen,James D’Rozario,Sarit Assouline,Carolyn Owen,John F. Gerecitano,Tadeusz Robak,Javier de la Serna,Ulrich Jaeger,Guillaume Cartron,Marco Montillo,Rod A. Humerickhouse,Elizabeth Punnoose,Yan Li,Michelle Boyer,Kathryn Humphrey,Mehrdad Mobasher,Arnon P. Kater +19 more
TL;DR: Among patients with relapsed or refractory chronic lymphocytic leukemia, venetoclax plus rituximab resulted in significantly higher rates of progression‐free survival than bendamustine plus r ituximac, and the benefit was maintained across all clinical and biologic subgroups.
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Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.
Jeffrey G. Gross,Adam R. Glassman,Lee M. Jampol,Seidu Inusah,Lloyd Paul Aiello,Andrew N. Antoszyk,Carl W. Baker,Brian B. Berger,Neil M. Bressler,David J. Browning,Michael J. Elman,Frederick L. Ferris,Scott M. Friedman,Dennis M. Marcus,Michele Melia,Cynthia R. Stockdale,Jennifer K. Sun,Roy W. Beck +17 more
TL;DR: Treatment with ranibizumab resulted in visual acuity that was noninferior to (not worse than) PRP treatment at 2 years, and may be a reasonable treatment alternative, at least through 1 years, for patients with proliferative diabetic retinopathy.
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Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial
Paulina Salminen,Hannu Paajanen,Tero Rautio,Pia Nordström,Markku Aarnio,Tuomo Rantanen,Risto Tuominen,Saija Hurme,Johanna Virtanen,Jukka-Pekka Mecklin,Juhani Sand,Airi Jartti,Irina Rinta-Kiikka,Juha Grönroos +13 more
TL;DR: Most patients randomized to antibiotic treatment for uncomplicated appendicitis did not require appendectomy during the 1-year follow-up period, and those who required appendectomy did not experience significant complications, despite the prespecified noninferiority margin.