X-ray luminescence optical tomography imaging: experimental studies
TLDR
A hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-Ray beams are used to excite phosphor-based contrast agents, is presented, in which as few as two orthogonal projection measurements are sufficient for XLOT reconstruction.Abstract:
We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents. Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent as priors. We demonstrate XLOT using phantom experiments with deep targets and show that the reconstructed signal varies by <12% when the depth changes from 4.2 to 7.7 mm. For simple source distributions, we find as few as two orthogonal projection measurements are sufficient for XLOT reconstruction.read more
Citations
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NaGdF4:Eu3+ Nanoparticles for Enhanced X-ray Excited Optical Imaging.
L. Sudheendra,Gautom Kumar Das,Changqing Li,Daniel Stark,Jake Cena,Simon R. Cherry,Ian M. Kennedy +6 more
TL;DR: A combination of high material density, higher atomic number and efficient NIR luminescence from compatible lanthanide dopant ions indicates that particles that consist of ALnF4 may offer a very attractive class of materials for high resolution, deep tissue imaging with X-ray excitation.
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X-Ray Luminescence and X-Ray Fluorescence Computed Tomography: New Molecular Imaging Modalities
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In vivo x-ray luminescence tomographic imaging with single-view data
Xin Liu,Qimei Liao,Hongkai Wang +2 more
TL;DR: This Letter first in vivo tomographically image the near-IR-emitting nanophosphor (Gd2O3:Eu3+) in nude mice and indicates that the single-view reconstruction is feasible to image XLCT in vivo.
Journal ArticleDOI
Numerical simulation of x-ray luminescence optical tomography for small-animal imaging
TL;DR: The heterogeneity of x-rays energy deposition is included in the XLOT-EP reconstruction and improves the reconstruction accuracy, suggesting that there is a need to calculate the x-ray energy distribution for experimental XLOT imaging.
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Radioluminescence in biomedicine: physics, applications, and models.
TL;DR: This review provides a comprehensive treatment of the physics of radioluminescence and includes simple analytical models to estimate the luminescence yield of scintillator and nanoscintillators, Cherenkov radiation, air fluorescence, and biologically endogenous radiolumscence.
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TL;DR: In vivo mouse experiments with BLT are described, and the reconstruction procedure of bioluminescent sources from optical data measured on the body surface of the mouse is proposed using a modality fusion approach.
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TL;DR: A hybrid imaging system for simultaneous fluorescence tomography and X-ray computed tomography of small animals has been developed and presented, and images from a brain imaging study are shown, which are reconstructed using XCT-derived priors into the optical forward problem.