Open Access
Zinc and immune system.
TLDR
The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn, which influence the function of immunostimulants used in the experimental systems and the therapeutic use of Zn will be discussed in detail.About:
The article was published on 2013-01-01 and is currently open access. It has received 428 citations till now. The article focuses on the topics: Acquired immune system & Immune receptor.read more
Citations
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The Essential Toxin: Impact of Zinc on Human Health
TL;DR: Rather than being a toxic metal ion, zinc is an essential trace element and plays a significant role in cytotoxic events in single cells in the brain, and cytotoxicity in consequence of ischemia or trauma involves the accumulation of free zinc.
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Zinc and human health: an update.
TL;DR: The zinc as a multipurpose trace element, its biological role in homeostasis, proliferation and apoptosis and its role in immunity and in chronic diseases, such as cancer, diabetes, depression, Wilson’s disease, Alzheimer's disease, and other age-related diseases are reviewed.
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Mycobacterium tuberculosis: success through dormancy
TL;DR: The molecular mechanisms underlying Mycobacterium tuberculosis's ability to shut down its own central metabolism, terminate replication, and thereby transit into a stage of dormancy rendering itself extremely resistant to host defense and drug treatment are reviewed.
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Zinc-Altered Immune Function
Klaus-Helge Ibs,Lothar Rink +1 more
TL;DR: Impaired immune functions due to zinc deficiency are shown to be reversed by an adequate zinc supplementation, which must be adapted to the actual requirements of the patient.
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Zinc is a novel intracellular second messenger
Satoru Yamasaki,Kumiko Sakata-Sogawa,Aiko Hasegawa,Tomoyuki Suzuki,Koki Kabu,Emi Sato,Tomohiro Kurosaki,Susumu Yamashita,Makio Tokunaga,Makio Tokunaga,Keigo Nishida,Toshio Hirano +11 more
TL;DR: The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcɛRI-mediated signaling.
References
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The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
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Dimerization of cell surface receptors in signal transduction
TL;DR: This review focuses on the role of dimerization of cell surface receptors in signal transduction, which appears to be a mechanism of general applicability for the regulation of signalTransduction.
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Zinc and immune function: the biological basis of altered resistance to infection.
TL;DR: Parts of zinc biology of the immune system are explored and a biological basis for the altered host resistance to infections observed during zinc deficiency and supplementation is attempted.
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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
Johanna Aaltonen,Petra Björses,Jaakko Perheentupa,Nina Horelli–Kuitunen,Aarno Palotie,Leena Peltonen,Yeon Su Lee,Fiona Francis,Steffen Henning,Cora S. Thiel,Hans Leharach,Marie-Laure Yaspo +11 more
TL;DR: A novel gene, AIRE, encoding for a putative nuclear protein featuring two PHD-type zinc-finger motifs is isolated, suggesting its involvement in transcriptional regulation in APECED, suggesting the molecular basis of autoimmunity.
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Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins.
TL;DR: The rapid increase in the number and nature of the proteins in which zinc functions is not unexpected since zinc is the second most abundant trace metal found in eukaryotic organisms, second only to iron.