Journal ArticleDOI
Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury.
TLDR
It is suggested that intracellular zinc release from MT-III may contribute substantially to zinc-mediated neuronal death in certain brain areas, including the hippocampal CA1 region and the thalamus.About:
This article is published in Experimental Neurology.The article was published on 2003-11-01. It has received 160 citations till now. The article focuses on the topics: Hippocampal formation & Dentate gyrus.read more
Citations
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Journal ArticleDOI
The neurobiology of zinc in health and disease
TL;DR: The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC, and the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'.
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Zinc in the physiology and pathology of the CNS.
TL;DR: The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial intra- and intercellular signalling ion of the CNS.
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Disparate roles of zinc in chemical hypoxia-induced neuronal death
TL;DR: Although intracellular Zn2+ release/accumulation is common during chemical hypoxia, Zn 2+ might differently influence the subsequent fate of neurons; it appears to play a neurotoxic or neuroprotective role depending on the hypoxic chemical used.
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Microglial activation in stroke: therapeutic targets.
TL;DR: A challenge will be to find ways to selectively suppress the deleterious effects of microglial activation after stroke without compromising neurovascular repair and remodeling.
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Alzheimer's disease, metal ions and metal homeostatic therapy
TL;DR: It is discussed how therapeutic strategies aimed at restoring metal homeostasis can delay and modify the progression of AD-related neurodegeneration.
References
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Journal ArticleDOI
The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
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Release of endogenous Zn2+ from brain tissue during activity.
S. Y. Assaf,S. H. Chung +1 more
TL;DR: It is demonstrated for the first time that Zn2+ is released into the extracellular space during excitation of hippocampal slices.
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The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia
TL;DR: The toxic influx of zinc may be a key mechanism underlying selective neuronal death after transient global ischemic insults and could be prevented by the intraventricular injection of a zinc chelating agent.
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Stimulation-induced uptake and release of zinc in hippocampal slices.
TL;DR: It is reported that the mossy-fibre neuropil and cells of origin (dentate granule cells) take up zinc preferentially, and that electrical stimulation selectively facilitates both uptake of exogenous zinc into mossY-f fibre neuro pil and release of previously incorporated 65Zn from the tissue.
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Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron
Christopher J. Frederickson,Sang Won Suh,David Silva,Cathy J. Frederickson,Richard B. Thompson +4 more
TL;DR: The present review outlines the methods used to discover, define and describe zinc-containing neurons; the neuroarchitecture and synaptology of zinc- containing neural circuits; the physiology of regulated vesicular zinc release; the "life cycle" and molecular biology of vesicle zinc; the importance of synaptically released zinc in the normal and pathological processes of the cerebral cortex; and the role of specific and nonspecific stressors in the release of zinc.