Can I delay the second dose of Covid vaccine?
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| Papers (11) | Insight |
|---|---|
| Summary COVID-19 vaccines are urgently needed and while single-dose vaccines are preferred, two-dose regimens may improve efficacy. | |
| We show that the answer to this question depends tightly on the efficacy of the first and the second COVID-19 vaccine doses. | |
| Use of a continuous measure of vaccine delay may be more informative and comparable. | |
2 Citations | In circumstances of vaccine shortage, delaying the second dose may be a pertinent public health strategy to consider. |
55 Citations | As recall memory for this vaccine is elicited several years after a single dose there is probably no need for a second vaccine dose. |
| A significant proportion of individuals over 80 appear to require a second dose of vaccine, given in this study at three weeks, to achieve virus neutralisation. | |
52 Citations | We have shown that it can be administered with a delay of up to 5 days after the start of vaccine treatment without significant antibody suppression within the first month. |
| In times of vaccine shortage, and until correlates of protection are identified, our findings preliminarily suggest the following strategy as more evidence-based: a) a single dose of vaccine for patients already having had laboratory-confirmed COVID-19; and b) patients who have had laboratory-confirmed COVID-19 can be placed lower on the vaccination priority list. | |
| It can be speculated that the level and duration of protection will improve after the second dose of vaccine is administered. | |
| Data obtained clearly showed that one vaccine dose is sufficient to increase both cellular and humoral immune response in ex COVID-19 subjects without any additional improvement after the second dose. | |
| Our findings underscore the importance of quantifying the durability of vaccine-induced protection after the first dose as well as vaccine efficacy against infection in order to determine the optimal time interval between the two doses. |
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