How stable are circular RNA molecules?
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Circular RNA molecules are highly stable . Their closed ends contribute to their stability, although they can still be degraded by circulating endonucleases or microRNA-mediated cleavage . Circular RNAs have been shown to be more stable than their linear mRNA counterparts in vivo . They can accumulate to higher levels than linear mRNAs and are expressed in a tissue- and stage-specific manner . Circular RNAs have the ability to sponge microRNAs and regulate cellular processes . They can also act as competing endogenous RNAs and control gene expression events . Circular RNAs have been found to be abundant, stable, conserved, and nonrandom products of RNA splicing . Their stability, conservation, and regulatory functions suggest that they likely impact many biological processes .
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| Papers (5) | Insight |
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47 Citations | The paper mentions that circular RNA molecules are more stable than their linear isoforms and can accumulate in cells with different division rates. |
| The provided paper does not mention anything about the stability of circular RNA molecules. | |
317 Citations | Circular RNAs are highly stable transcripts that often accumulate in the cytoplasm. |
3.3K Citations | Circular RNA molecules are more stable than associated linear mRNAs in vivo. |
49 Citations | Circular RNA molecules are more stable than linear RNA molecules, with a half-life of more than 48 hours compared to 10 hours for linear RNA. However, in serum, the stability of circRNAs is reduced to around 15 seconds due to the presence of circulating endonucleases. |
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