J
Jessica A. Sorrentino
Researcher at Research Triangle Park
Publications - 47
Citations - 5308
Jessica A. Sorrentino is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Chemotherapy & Cancer. The author has an hindex of 14, co-authored 46 publications receiving 3848 citations. Previous affiliations of Jessica A. Sorrentino include University of North Carolina at Chapel Hill.
Papers
More filters
Journal ArticleDOI
Circular RNAs are abundant, conserved, and associated with ALU repeats
William R. Jeck,Jessica A. Sorrentino,Kai Wang,Michael K. Slevin,Christin E. Burd,Jinze Liu,William F. Marzluff,Norman E. Sharpless +7 more
TL;DR: High-throughput sequencing of libraries prepared from ribosome-depleted RNA with or without digestion with the RNA exonuclease showed that ecircRNAs are abundant, stable, conserved and nonrandom products of RNA splicing that could be involved in control of gene expression.
Journal ArticleDOI
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
Jiehui Deng,Jiehui Deng,Eric S. Wang,Russell W. Jenkins,Shuai Li,Ruben Dries,Kathleen B. Yates,Sandeep Chhabra,Wei Huang,Hongye Liu,Amir Reza Aref,Elena Ivanova,Cloud P. Paweletz,Michaela Bowden,Chensheng W. Zhou,Grit S. Herter-Sprie,Jessica A. Sorrentino,John E. Bisi,Patrick H. Lizotte,Ashley A. Merlino,Max M. Quinn,Lauren E. Bufe,Annan Yang,Yanxi Zhang,Hua Zhang,Peng Gao,Ting Chen,Megan E. Cavanaugh,Amanda J. Rode,Eric Haines,Patrick J. Roberts,Jay C. Strum,William G. Richards,Jochen H. Lorch,Sareh Parangi,Viswanath Gunda,Genevieve M. Boland,Raphael Bueno,Sangeetha Palakurthi,Gordon J. Freeman,Gordon J. Freeman,Jerome Ritz,W. Nicholas Haining,Norman E. Sharpless,Haribabu Arthanari,Geoffrey I. Shapiro,Geoffrey I. Shapiro,David A. Barbie,David A. Barbie,Nathanael S. Gray,Kwok-Kin Wong +50 more
TL;DR: It is shown that short-term exposure to small-molecule inhibitors of cyclin-dependent kinases 4 and 6 significantly enhances T- cell activation, contributing to antitumor effects in vivo, due in part to the derepression of NFAT family proteins and their target genes, critical regulators of T-cell function.
Journal ArticleDOI
Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.
Christin E. Burd,Jessica A. Sorrentino,Kelly S. Clark,David B. Darr,Janakiraman Krishnamurthy,Allison M. Deal,Nabeel Bardeesy,Diego H. Castrillon,David H. Beach,Norman E. Sharpless +9 more
TL;DR: It is suggested that p16(INK4a) activation is a characteristic of all emerging cancers, making the p 16(LUC) allele a sensitive, unbiased reporter of neoplastic transformation.
Journal ArticleDOI
Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.
Hanna K. Sanoff,Allison M. Deal,Janakiraman Krishnamurthy,Chad Torrice,Patrick M. Dillon,Jessica A. Sorrentino,Joseph G. Ibrahim,Trevor A. Jolly,Grant R. Williams,Lisa A. Carey,Amy Drobish,Brittaney Belle E. Gordon,Shani Alston,Arti Hurria,Karin Kleinhans,K. Lenhard Rudolph,Norman E. Sharpless,Hyman B. Muss +17 more
TL;DR: Adjuvant chemotherapy for breast cancer is gerontogenic, inducing cellular senescence in vivo, thereby accelerating molecular aging of hematopoietic tissues.
Journal ArticleDOI
Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence
Jie-Yu Liu,George P. Souroullas,Brian O. Diekman,Janakiraman Krishnamurthy,Brandon M. Hall,Jessica A. Sorrentino,Joel S. Parker,Garrett A. Sessions,Andrei V. Gudkov,Norman E. Sharpless +9 more
TL;DR: A reporter allele is described, p16tdTom, enabling the in vivo identification and isolation of cells featuring high-level activation of the p16INK4a promoter, displaying characteristics of senescence.