What are the current challenges in achieving fine-tuned signal enhancements in in vivo fluorescence and SERS experiments?
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Achieving fine-tuned signal enhancements in in vivo fluorescence and SERS experiments faces several challenges. One challenge is the interference of fluorescence signals from analyte molecules, which can hinder the detection of Raman scattering signals . Another challenge is the need for a proper match between the SERS substrate and light to obtain stable and sensitive SERS substrates . Additionally, the modification of vibrational modes, breakdown of molecules, and tunneling regime can limit the enhancement of localized hot spot fields in SERS experiments . Furthermore, identifying protein structures at low concentrations, especially in equilibrium mixtures of various conformations, is a challenging task . These challenges highlight the need for improved techniques and methods to overcome the limitations and achieve better signal enhancements in in vivo fluorescence and SERS experiments.
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29 Citations | The provided paper does not discuss the challenges in achieving fine-tuned signal enhancements in in vivo fluorescence and SERS experiments. |
68 Citations | The provided paper does not discuss the challenges in achieving fine-tuned signal enhancements in in vivo fluorescence and SERS experiments. |
| The provided paper does not discuss the current challenges in achieving fine-tuned signal enhancements in in vivo fluorescence and SERS experiments. | |
41 Citations | The provided paper does not mention any challenges in achieving fine-tuned signal enhancements in in vivo fluorescence and SERS experiments. The paper focuses on the simultaneous existence of Raman scattering enhancement and inhibiting fluorescence during SERS detection using surface modified gold nanostars. |
| The provided paper does not discuss the challenges in achieving fine-tuned signal enhancements in in vivo fluorescence and SERS experiments. |
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