What is the best growth hormone releasing peptide?
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157 Citations | Growth hormone and its associated peptide, insulin-like growth factor-I, are now known to provide chronic lipolytic, diabetogenic, and gluconeogenic signals to target tissues culminating in increased mammary gland availability of glucose and nonesterified fatty ac... |
| Enhancement of the amphiphilic alpha-helical properties of the central and C-terminal regions of growth hormone-releasing hormone (GRH) by substitution with helix-favouring amino acids, particularly Ala, can result in significant improvements in GH-releasing potencies using monolayer cultures of rat pituitary cells, a system which reflects analogue receptor affinity rather than effects of structural modifications on pharmacokinetic properties. | |
| Of these, GH-releasing hormone (GHRH) plus arginine and GHRH plus GH-releasing peptide (GHRP) appear to be reliable and practical. | |
8K Citations | Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. |
| were found for hydrophobic derivative-growth hormone and standard growth hormone during this phase, indicating rapid removal of drug from the circulation. | |
| Gonadotropin-releasing hormone appears to have the properties of a growth hormone-releasing factor. | |
| Further work demonstrated that this peptide met the criteria established for a releasing hormone. | |
26 Citations | These results (1) provide immunocytological evidence for the presence of growth hormone-releasing factor or of an immunoreactive fragment of its molecule in the pituitary; (2) indicate the presence of this peptide in one particular pituitary cell type; and (3) provide cytological evidence for direct participation of growth hormone-releasing factor in the regulation of the somatotropic function. |
| The approach described is applicable to several related peptide hormones, like growth hormone-releasing hormone and secretin. | |
| A complete vindication of this view now appears in sight with the recent discovery of a peptide with specific and unusually potent stimulatory effects on growth hormone (GH) secretion. | |
1.1K Citations | In addition, synthetic growth hormone secretagogues have also been shown to regulate growth hormone release through the growth hormone secretagogue receptor (GHS-R), suggesting the existence of an additional physiological regulator for growth hormone release. |
31 Citations | Exogenous growth hormone was capable of inhibiting endogenous growth hormone release, suggesting the existence of an “auto” feed-back mechanism. |
| It is clear from these studies that further developments are necessary to demonstrate the practical application of growth hormone-releasing factor. | |
179 Citations | We have now found more direct evidence for a hypothalamic action of growth hormone-releasing peptide in two ways. |
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