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Nancy G. Isern
Researcher at Environmental Molecular Sciences Laboratory
Publications - 69
Citations - 3226
Nancy G. Isern is an academic researcher from Environmental Molecular Sciences Laboratory. The author has contributed to research in topics: Extracorporeal membrane oxygenation & Lignin. The author has an hindex of 27, co-authored 69 publications receiving 2465 citations. Previous affiliations of Nancy G. Isern include Pacific Northwest National Laboratory & Boston University.
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Journal ArticleDOI
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Gil Sharon,Nikki Jamie Cruz,Dae Wook Kang,Michael J. Gandal,B. D. Wang,Young-Mo Kim,Erika M. Zink,Cameron P. Casey,Bryn C. Taylor,Christianne J. Lane,Lisa M. Bramer,Nancy G. Isern,David W. Hoyt,Cecilia Noecker,Michael J. Sweredoski,Annie Moradian,Elhanan Borenstein,Janet K. Jansson,Rob Knight,Thomas O. Metz,Carlos Lois,Daniel H. Geschwind,Rosa Krajmalnik-Brown,Sarkis K. Mazmanian +23 more
TL;DR: It is proposed that the gut microbiota regulates behaviors in mice via production of neuroactive metabolites, suggesting that gut-brain connections contribute to the pathophysiology of ASD.
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Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders.
Dae Wook Kang,Zehra Esra Ilhan,Nancy G. Isern,David W. Hoyt,Daniel P. Howsmon,Michael Shaffer,Catherine A. Lozupone,Juergen Hahn,James B. Adams,Rosa Krajmalnik-Brown +9 more
TL;DR: The data in this study support that children with ASD have altered metabolite profiles in feces when compared with neurotypical children and warrant further investigation of metabolites in larger cohorts.
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c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry.
TL;DR: It is demonstrated that endogenous c-myc increased 13C labeling of ribose sugars, purines and amino acids, indicating partitioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic acid cycle turnover at the expense of anaplerotic flux.
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Contribution of extracellular polymeric substances from Shewanella sp. HRCR-1 biofilms to U(VI) immobilization
Bin Cao,Bulbul Ahmed,David W. Kennedy,Zheming Wang,Liang Shi,Matthew J. Marshall,James K. Fredrickson,Nancy G. Isern,Paul D. Majors,Haluk Beyenal +9 more
TL;DR: The goal of this study was to quantify the contribution of extracellular polymeric substances (EPS) to U(VI) immobilization by Shewanella sp.
Journal ArticleDOI
Evidence supporting dissimilatory and assimilatory lignin degradation in Enterobacter lignolyticus SCF1
Kristen M. DeAngelis,Deepak Sharma,Rebecca M. Varney,Blake A. Simmons,Blake A. Simmons,Nancy G. Isern,Lye Meng Markilllie,Carrie D. Nicora,Angela D. Norbeck,Ronald C. Taylor,Joshua T. Aldrich,Errol W. Robinson +11 more
TL;DR: Transcriptomics and proteomics were used to examine the observed increased growth of SCF1 grown on media amended with lignin compared to unamended growth, and suggested the use of lign in as terminal electron acceptor, showing the advantages of a multi-omics approach toward providing insights as to how lignIn may be used in nature by microorganisms coping with poor carbon availability.