Showing papers on "Alkoxy group published in 1972"

Sulfur containing organosilicon compounds

Abstract: 1. A PROCESS OF PREPARIG A COMPOUND HAVING THE FORMULA Z-ALK-SN-ALK-Z, IN WHICH Z IS -SI(-R1)2-R2, -SI(-R2)2-R1, OR -SI(-R2)3 WHEREIN R1 IS ALKYL OF 1 TO 4 CARBON ATOMS OR PHENYL AND R2 IS ALKOXY OF 1 TO 8 CARBON ATOMS, CYCLOALKOXY WITH 5 TO 8 CARBON ATOMS OR ALKYLMERCAPTO WITH 1 TO 8 CARBON ATOMS, ALK IS A DIVALENT HYDROCARBON OF 1 TO 18 CARBON ATOMS AND N IS AN INTEGER OF 2 TO 6 COMPRISING REACTING A COMPOUND OF THE FORMULA Z-ALK-HAL WITH A COMPOUND OF THE FORMULA ME2SN WHERE ME IS AMMONIUM, ALKALI METAL OR AN ALKALINE EARTH METAL AND HAL IS A HALOGEN OF ATOMIC WEIGHT 35 TO 127

Jet printing ink composition

Abstract: 1. AN INK COMPOSITION CONSISTING ESSENTIALLY OF AN AQUEOUS SOLUTION OF 0.5 TO 7.0% BY WEIGHT OF A WATER-SOLUBLE DIRECT DYE AND 5 TO 40% BY EIGHT OF A HUMECTANT SYSTEM FORMED OF A MIXTURE OF A LOWER ALKOXY TRIGLYCOL AND AT LEAST ONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF A POLYETHYLENE GLYCOL HAVING AN AVERAGE MOLECULAR WEIGHT UP TO ABOUT 600, POLYPROPYENE GLYCOL HAVING AN AVERAGE MOLECULAR WEIGHT UP TO AOUT 425, A LOWER ALKYL ETHER OF ETHYLENE GLYCOL AND DITHYLENE GLYCOL, PROPYLENE GLYCOL AND GLYCEROL, WITH THE WEIGHT RATIO OF THE ALKOXY TRIGLYCOL TO SAID COMPOUND BEING WITHIN THE RANGE OF 0.1 TO 3.0, THE INK COPOSITION HAVING A VISCOSITY WITHIN THE RANGE OF 1.0 TO 10 CENTIPOISE AT 25*C. AND A SPECIFIC RESISTIVITY LESS THAN 150 OHM-CM.

Phenoxy-alkyl-carboxylic acid compounds

Abstract: NOVEL PHENOXY-ALKYL-CARBOXYLIC ACID COMPOUNDS OF THE FORMULA: (R1,R2-PHENYL)-CO-NH-(CH2)N-(1,4-PHENYLENE)-O-C(-R3)(-R4)- AND THE PHARMACOLOGICAL COMPATIBLE SALTS THEREOF, ARE REMARKABLY EFFECTIVE IN LOWERING THE SERUM LIPID LEVEL AND CHOLESTEROL LEVEL WITHOUT INDUCING UNDESIRABLE SIDE EFFECTS. R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN, HALOGEN, LOWER ALKYL OR LOWER ALKOXY; R3 AND R4, WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN OR LOWER ALKYL; N IS 1, 2 OR 3; AND Z IS HYDROXYL OR LOWER ALKOXY; WHEREIN CO-Z

Substituted 2-phenoxy alkane-sulfonanilides

Abstract: 1. A COMPOUND OF THE FORMULA: 1-(RX-SO2-N(-R)-),2-(Z(N'')-PHENYLENE-O-),4-Y,5-X,Z-BENZENE WHEREIN RX IS AN OPTIONALLY HALOGENATED ALKYL RADICAL, R IS HYDROGEN, ALKYL OR A PHARMACEUTICALLY ACCEPTABLE CATION, X IS ALKOXY, ALKYL, HALOGEN, ACETAMIDO, NITRO, HYDROGEN, AMINO, ALKOXYCARBAMOYL OR DIALKYLAMINO, Y IS NITRO, AMINO, ALKOXYCARBAMOYL, DIALKYLAMINO OR HYDROGEN, PROVIDED THAT ONE OF X AND Y IS NITRO, AMINO, ALKOXYCARBAMOYL, OR DIALKYLAMINO, Z IS HALOGEN, NITRO, OR HYDROGEN, Z'' IS HALOGEN, ALKYL, ALKOXY, NITRO, AMINO, ALKANAMIDO, HALOALKYL, HYDROXY, DIALKYLAMINO, ALKOXYCARBAMOYL, ALKYLTHIO, ALKYLSULFONYL, ALKANOYL, OR ALKYLSULFINYL AND N IS 0-2, PROVIDED THAT THE INDIVIDUAL ALIPHATIC GROUPS APPEARING TO THE RX, R, X, Y, AND Z'' MOIETIES CONTAIN FROM ONE TO FOUR CARBON ATOMS EACH.

6-phenyl-4h-s-triazolo(4,3-a)+8 1,4)benzodiazepines

Abstract: Procedure for the production of 6-phenyl-4H-s-triazolo- [4,3-a] [1,4] benzodiazepines of the formula (IV): **(See formula)** wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms inclusive, phenyl, benzyl and -COOR'where R' is alkyl of 1 to 4 carbon atoms inclusive; wherein R1 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms inclusive; and wherein R2, R3, R4 and R5 are selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms inclusive, halogen, nitro, cyano, trifluoromethyl and alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoylamino and dialkylamino where the carbon chain halves have from 1 to 3 carbon atoms inclusive, and their pharmacologically acceptable acid addition salts, characterized in that it consists of: condensing 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine -2thion of formula (I): **(See formula)** wherein R1, R2, R3, R4 and R5 are defined as above with an acid hydrazide of formula II: **(See formula)** wherein R is defined as above, with an organic solvent to obtain a mixture containing the corresponding compound of formula IV above, and the corresponding 2- (2-acylhydrazino) -5-phenyl-3H-1,4-benzodiazepine of formula III: **(See formula)** where R, R1, R2, R3, R4 and R5 are defined as above; and heating said mixture to about 250oC. to convert the product of formula III into the desired compound of formula IV. (Machine-translation by Google Translate, not legally binding)

Pyrrolo (3,4-b) pyrazine derivatives

Abstract: The new compounds of the formula: WHEREIN A is a phenyl, pyridyl, pyridazinyl or 2-, 3-or 4quinolyl radical optionally substituted by halogen, alkyl of 1 through 4 carbon atoms, alkoxy of 1 through 4 carbon atoms, cyano and nitro, and n is zero or 1, possess pharmacological properties, and are particularly active as tranquillisers and anti-convulsant agents.

Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants

Abstract: A shaped body in vivo implantation dosage form which is a dry composition containing a therapeutically active material and a water insoluble hydrophilic acrylate or methacrylate polymer selected from the group consisting of polymers of hydroxy lower alkyl acrylates, hydroxy lower alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates and hydroxy lower alkoxy lower alkyl methacrylates, said shaped body being formed by casting or molding an anhydrous casting syrup or solution of the therapeutic material and the hydrophilic acrylate or methacrylate and polymerizing the composition, the resulting cast or molded dosage form having the advantage of preventing deterioration or loss of potency and thereby extending the shelf life of the therapeutic.

1-aroylalkyl-4-diphenylmethyl piperidines

Abstract: NOVEL COMPOUNDS USEFUL AS ANTIHISTAMINE AGENTS, ANTIALLERGY AGENTS, AND BRONCHODILATORS ARE REPRESENTED BY THE FOLLOWING FORMULA 1-(Z-CO-(CH2)N-),4-((PHENYL)2-C(-R)-),4-R1-PIPERIDINE WHEREIN R REPRESENTS HYDROGEN OR HYDROXY; R1 REPRESENTS HYDROGEN; OR R AND R1 TAKEN TOGETHER FROM A SECOND BOND BETWEEN THE CARBON ATOMS BEARING R AND R1; N IS A POSITIVE WHOLE INTEGER OF FROM 1 TO 3; Z REPRESENTS THIENYL, PHENYL, OR SUBSTITUTED PHENYL WHEREIN THE SUBSTITUENTS ON THE SUBSTITUTED PHENYL MAY BE ATTACHED AT THE ORTHO, META, OR PARA POSITIONS OF THE PHENYL RING AND ARE SELECTED FROM HALOGEN, A STRAIGHT BRANCHED LOWER ALKYL CHAIN OF FROM 1 TO 4 CARBON ATOMS, A LOWER ALKOXY GROUP OF FROM 1 TO 4 CARBON ATOMS, DI(LOWER) ALKYLAMINO, OR A SATURATED MONOCYCLIC HETEROCYLIC GROUP SUCH AS PYRROLIDINO, PIPERIDINO, MORPHOLINO, OR N-(LOWER) ALKYLPIPERAZINO. PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND INDIVIDUAL OPTICAL ISOMERS OF COMPOUNDS OF THE ABOVE FORMULA ARE ALSO INCLUDED AS A PART OF THIS INVENTION.

Nuclear Magnetic Resonance Spectroscopy in Liquids containing Compounds of Aluminium and Gallium

Abstract: Publisher Summary In the last few years, there has been the discovery and characterization of a number of complexes of aluminium and of gallium, by nuclear magnetic resonance (NMR). The solvation complexes are reported with water, dimethylformamide, N-methyl acetamide, ammonia, dimethyl sulphoxide, acetonitrile, and some mixed complexes containing either one of these components or acetone or tetrahydrofuran together with water. The solvation number for water on aluminium ion AP3⊕ is established as integrally six. Replacement of solvation water occurs by sulphate ion, phosphoric acid and dihydrogen phosphate ions, and by fluoride ion. The chapter describes the trisubstituted aluminium and gallium compounds, that have a general formula [MXYZ]n, where M is the metal and the substituents XYZ may be alkyl alkoxy, halide, siloxy, germyloxy, or various nitrogen bonded groups. Adducts of the substituted alanes and gallanes have some similarities to the dimers, as the dimers may be regarded as self adducts with a donor and acceptor centre in each half molecule. The metal chemical shifts are reported with respect to the ions M(H2O)3⊕6 whose shifts appear to be virtually independent of concentration. The formation of adducts produces a low-field shift that appears to depend upon the nature of the donor atom rather than upon the strength of the complex. The line widths of these molecules are very much broader than the tetrahedral species found to higher field.

Alkanedioxy titanium chelates

Abstract: Alkanedioxy titanium chelates have the formula: WHEREIN R2 is a radical selected from the group consisting of hydrogen, hydrocarbyl having not more than about 8 carbon atoms, carboxyalkyl and halohydrocarbyl having not more than about 8 carbon atoms and the total number of carbon atoms in the R2 and R6 substituted alkanedioxy radical is not more than about 18, R3 is a radical having not more than about 8 carbon atoms selected from the group consisting of hydrocarbyl, halohydrocarbyl and cyano lower alkyl, R6 can be selected from the same group as R2 and in addition can be halo, cyano, nitro, carboxy ester, acyl and hydrocarbly substituted by halo, cyano, nitro, carboxy ester and acyl, R7 is selected from the group consisting of hydrogen, hydrocarbyl, halohydrocarbyl, acyl, and taken together with R3 can form together with the carbon atoms to which they are attached cyclichydrocarbon substituents and chloro, nitro, acyl, cyano and carboxy ester substituted cyclic hydrocarbon substituents; X is a radical selected from the group consisting of hydrocarbyl, halohydrocarbyl, cyanoalkyl, alkoxy, haloalkoxy, cyanoalkoxy and amino, and n has a value of 0 to 8, and when X is methyl the alkanedioxy substituent is other than an ethanedioxy or a 2,2-dimethyl-1,3-propanedioxy substituent. When mixed with methyltrimethoxysilane and a silanol chainstopped polydiorganosiloxane fluid, these chelates catalyze the cure of the composition to a rubbery solid elastic state when exposed to atmospheric moisture.

Olefinic 4-substituted piperidino derivatives

Abstract: Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula WHEREIN R and R1 each represent hydrogen; or R and R1 taken together form a second bond between the carbon atoms bearing R and R1; n is a positive whole integer of from 1 to 3; Y represents -CH=CH-, or WITH THE PROVISO THAT WHEN EACH OF R and R1 represents hydrogen, Y represents -CH=CH, and when Y represents -CH=CH, n is equal to 1 or 2; and Z represents thienyl, phenyl, or substituted phenyl wherein the substituents on the substituted phenyl may be attached at the ortho, meta, or para positions of the phenyl ring and are selected from halogen, a straight or branched lower alkyl chain or from 1 to 4 carbon atoms, a lower alkoxy group of from 1 to 4 carbon atoms, di(lower)-alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)-alkylpiperazino Pharmaceutically acceptable acid addition salts and individual geometric isomers of compounds of the above formula are also included as a part of this invention

Silylhydrocarbyl phosphines and related compounds

Abstract: Novel heterogeneous silylhydrocarbyl phosphine transition metal complex catalysts and intermediates therefore are prepared by (a) the selective monoaddition of silanes having chlorine, alkoxy or acyloxy groups to an alpha , omega -diene (b) followed by the addition of a phosphine to the resulting omega -alkenyl silanes to form the corresponding silylalkyl phosphines (c) which are then covalently anchored as such or in the form of their transition metal complexes via condensation of their reactive silane substituents with hydroxy groups of silica and metal oxides, (d) optionally followed by complexing the free phosphine groups of anchored silylalkyl phosphines with transition metal compounds.

The Synthesis of some α-Cyclopropylcarbonyl Glycopyranosides

Abstract: The syntheses of three α-cyclopropylcarbonyl compounds of carbohydrate origin, 1, 2, 3, are described. The cyclopropyl carboxaldehyde 1 was obtained from the corresponding carbinol by manganese dioxide oxidation of the primary alcohol. However, the secondary cyclopropyl alcohol in 8 did not respond to manganese dioxide and its oxidation (in the tritylated derivative (14), to the cyclopropyl ketone, 2, had to be achieved by ruthenium tetroxide. The sequence leading to 2 (via 8) began with ethyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside 11, which added methylene to give the α-D-allo configuration with the cyclopropane ring syn to the glycosidic ethoxy group. The diastereomeric tritylated cyclopropyl ketone 3, possessing the cyclopropyl ring anti to the ethoxy group, resulted from cyclopropanation of the αβ-un-saturated ketone, 15. In the latter case, the acetoxy group apparently provides greater directing influence to the incoming methylene than does the allylic ethoxy group.

Liquid Crystals VII. The Mesomorphic Behavior of Homologous:p-Alkoxy-p'-Acyloxyazoxybenzenes

Abstract: In a continued effort to synthesize compounds which exhibit nematic mesomorphism at room temperature, homologous p-alkoxy-p'-acyloxyazobenzenes and p-alkoxy-p'-acyloxyazoxybenzenes were prepared. The p-substituted groups were normal alkyl chains containing from one to seven carbon atoms. Of the 98 compounds which were prepared in both the azo and azoxy series, 87 exhibited enantiotropic and 3 monotropic nematic properties while only 8 showed smectic behavior. The azoxy “compounds” were generally lower melting than the azo compounds. This is presumably due to the fact that the former are mixtures of isomers (oxygen may be on nitrogen attached to the alkoxyphenyl group or on nitrogen attached to the acyloxyphenyl group). The higher nematic thermal stability of the azoxy materials compared to the azo compounds and to analogous Schiff base compounds may be attributed to broadening of the molecule as a result of the presence of a lateral oxygen atom. This would have the effect of increasing the termin...

4(3-Carboxy-4-hydroxyphenylazo)-benzenlsulphonamide pyridine compounds having immunosuppressive effects

Abstract: The compound: The compound:COOH ¦ A-NH-SO2-N=N-OH where A is either (1) WHERE R1; R2 and R3 are either hydrogen, lower alkyl, halogen, lower alkoxy, cyano, nitro or carboxamide and R4 is either lower alkyl, halogen, lower alkoxy, cyano, nitro or carboxamide, or (2) R1'R2' ANGLE R3' ¦R4' where R1'; R2'; R3' and R4' are either hydrogen, lower alkyl, halogen, lower alkoxy, cyano, nitro or carboxamido.

Oxalic acid diarylamides

Abstract: Disclosed are oxalic acid diarylamides as ultraviolet absorbing agents for organic materials, the oxalic acid diarylamides being compounds of the formula A - NH - CO - CO - NH - A in which A represents a member selected from the group consisting of IN WHICH Z represents a member selected from the group consisting of a linear or branched alkyl group with 1 to 18 carbon atoms, an acetyl, butyryl, lauroyl, octadecanoyl, benzoyl, para-tertiary butylbenzoyl or para-chlorobenzoyl group, a benzyl group, a carbalkoxyalkyl group with a total of up to 12 carbon atoms, an allyl group and a mono-halogenalkyl group with up to 8 carbon atoms; Z1 represents an alkyl or mono-halogenalkyl group containing 1 to 18 carbon atoms; R19 represents an alkyl group containing 1 to 12 carbon atoms, w is 1, 2 or 3; X represents a member selected from the group consisting of an alkyl group with up to 12 carbon atoms, a halogen atom, a phenyl and a cyclohexyl group; and Y1 and Y3 each stands for hydrogen, an alkyl or alkoxy group with 1 to 8 carbon atoms, or Y2 may also represent a phenyl group; W represents an alkyl group with 1 to 18 carbon atoms or a carbalkoxyalkyl group with 3 to 8 carbon atoms.

Di(dialkylamino alkoxy)phenanthridines as antiviral agents

Abstract: PHENANTHRIDINES AND PHENANTHRIDINONES OF THE FORMULA 6-X,(R1-N(-R2)-A-O-)2-PHENANTHRIDINE I 5-R,Y,Z-5,6-DIHYDROPHENANTHRIDIN-6-ONE II AND THE PHARMACEUTICALLY-ACCEPTABLE ACID ADDITON SALTS THEREOF WHEREIN X IS CHLORO, BROMO, HYDROXY, ALKOXY HAVING FROM 1 TO 6 CARBON ATOMS, AMINO, MONOALKYLAMINO, DIALKYLAMINO WHEREIN EACH OF THE ALKYL GROUPS HAS FROM 1 TO 6 CARBON ATOMS, AND BENZYLAMINO; R IS HYDROGEN, ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, -A-NR1R2 WHEREIN EACH OF R1 AND R2 IS ALKYL HAVING FROM 1 TO 6 CARBON ATOMS AND A IS A DIVALENT ALKYLENE RADICAL HVING FROM 2 TO 6 CARBON ATOMS; AND EACH OF Y AND Z IS HYDROGEN, AND WDIALKYLAMINOALKOXY WHEREIN THE ALKYL AND ALKOXY GROUPS HAVE FROM 1 TO 6 CARBON ATOMS AND FROM 2 TO 6 CARBON ATOMS, RESPECTIVELY; WITH THE PROVISO THAT WHEN R IS HYDROGEN OR ALKYL, EACH OF Y AND Z IS DIALKYLAMINOALKOXY; USEFUL AS ANTIVIRAL AGENTS AND/OR INTERFERON INDUCERS AND METHODS FOR THEIR PREPARATION.

Sulfonamide herbicide antidote compositions and method of use

Abstract: Herbicidal compositions consisting of an active herbicidal compound and an antidote therefor and the methods of use of the herbicide compositions are described herein. The antidote compound corresponds to the formula ##STR1## wherein R1 can be selected from the group consisting of alkyl, haloalkyl, halogen, isocyanate, alkenylamino, halophenylamino, phenyl, substituted phenyl wherein said substituents can be selected from alkyl, alkoxy, halogen, nitro, amino and haloalkylaminosulfonyl; R2 and R3 can be the same or different and can be selected from hydrogen, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, alkynoxy, haloalkoxycarbonyl, alkynoxycarbonyl, carbamoyl, haloalkylthio, diacetonitrilocarbamyl, phenyl, substituted phenyl wherein said substituents can be selected from alkoxy, halogen, hydroxy, nitro and carbamoyl, and R2 and R3 taken together form the ring structure alkyloxazolidyl.

D-ring substituted 6-deoxytetracyclines

Abstract: 1. A COMPOUND SELECTED FROM THE GROUP CONSISTING OF THOSE HAVING THE FORMULAE 1-(R4-N(-R3)-),2,4,5,6-TETRA(O=),3-X4,4A-(HO-),7-X2,9-X, 10-X1,11-A-1,2,3,4,5,6,11,12-OCTAHYDRONAPHTHACENE AND 1-(R4-N(-R3)-),2,4,5,6-TETRA(O=),3-X4,7-X2,9-X,10-X1,11-A- 1,2,3,4,5,6,11,12-OCTAHYDRONAPHTHACENE WHEREIN X IS SELECTED FROM THE GROUP CONSISTING OF AMINO, MONOLOWER ALKYLAMINO, ALKANOYLAMINO HAVING 2 TO 4 CARBON ATOMS, LOWER ALKYL AND LOWER ALKOXY; X1 IS SELECTED FROM THE GROUP CONSISTING HYDROGEN AND CHLORO; X2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROXY AND LOWER ALKOXY; A IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL; R3 AND R4 WHEN TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A NITROGEN HETEROCYCLIC RING SELECTED FROM THE GROUP CONSISTING OF PIPERAZINO, PIPERIDINO, MORPHOLINO, PYRROLO, THIOMORPHOLINO, PYRROLIDINO AND 2-(LOWER CARBALKOXY)PYRROLIDINO; R3 AND R4 WHEN TAKEN SEPARATELY ARE EACH SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKANOYL HAVING 1 TO 4 CARBON ATOMS, AND CH2B1 WHEREIN B1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL AND MONO-SUBSTITUTED LOWER ALKYL, SAID SUBSTITUENT BEING SELECTED FROM THE GROUP CONSISTING OF HYDROXY AND LOWER ; PROVIDED THAT ONLY ONE OF SAID R3 AND R4 SUBSTITUENTS IS SELECTED FROM THE GROUP CONSISTING OF ALKANOYL HAVING 1 TO 4 CARBON ATOMS; X4 IS SELECTED FROM THE GROUP CONSISTING OF CYANO AND -CO-NH-R6 WHEREIN R6 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL.

2-Thienyl azo dyestuff compounds

Abstract: Azo compounds having the formula ##STR1## in which R1 is cyano, aryl, an acyl radical or a carbamoyl radical, R2 is hydrogen, alkyl, alkoxy, aralkyl or aryl, R3 is alkyl, halogen, thiocyanato, arylazo or one of the substituents which R1 can represent, and A is an aniline, tetrahydroquinoline, benzomorpholine or α-naphthylamine disperse azo dye coupling component. The azo compounds produce red to blue shades on polyamide, polyester and cellulose acetate fibers and exhibit improved fastness and dyeability properties on synthetic polyamide fibers.

1-carbolower alkoxy - 6 - phenyl-4h-s-triazolo(1,4)benzodiazepine compounds

Abstract: 6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINES OF THE FORMULA IV: 1-R,4-R1,6-(R2,R3-PHENYL),R4,R5-4H-1,2,4-TRIAZOLO(4,3-A) (1,4)BENZODIAZEPINE WHEREIN R IS~COOR'' IN WHICH R'' IS ALKYL OF 1 TO 4 CARBON ATOMS, INCLUSIVE; WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL OF 1 TO 3 CARBON ATOMS, INCLUSIVE; AND WHEREIN R2, R3, R4, AND R5 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL OF 1 TO 3 CARBON ATOMS, INCLUSIVE, HALOGEN, NITRO, CYANO, TRIFLUOROMETHYL, AND ALKOXY, ALKYLTHIO, ALKYLSULFINYL, ALKYLSULFONYL, ALKANOYLAMINO AND DIALKYLAMINO IN WHICH THE CARBON CHAIN MOIETIES ARE OF 1 TO 3 CARBON ATOMS, INCLUSIVE, ARE PRODUCED BY CONDENSING A 1,3-DIHYDRO-5PHENYL-2H-1,4-BENZODIAZEPINE-2-THIONE OF THE FORMULA I: 2-(S=),3-R1,6-(R2,R3-PHENYL),R4,R5-3H-1,2-DIHYDRO-3H- (1,4)BENZODIAZEPINE WHEREIN R1, R2, R3, R4, AND R5 ARE DEFINED AS ABOVE WITH AN ORGANIC ACID HYDRAZIDE OF THE FORMULA: H2N-NH-CO-R WHEREIN R IS DEFINED AS ABOVE. THE NEW PRODUCTS OF FORMULA IV INCLUDING THEIR PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS ARE USEFUL AS SEDATIVES, TRANQUILIZERS AND MUSCLE RELAXANTS IN MAMMALS AND BIRDS.