Showing papers on "Garcinia cambogia published in 2020"

Garcinia spp. extract incorporated icing medium as a natural preservative for shelf life enhancement of chilled Indian mackerel (Rastrelliger kanagurta)

Abstract: The present study investigates the use of a novel icing medium containing aqueous extract of two varieties of Garcinia fruit rinds, the culinary spices exhibiting antioxidant and antimicrobial activities, for the preservation of fish during chilled storage. Aqueous extracts of Garcinia indica and Garcinia cambogia were prepared and its phenolic content, antioxidant activities and antimicrobial properties were studied. Four icing media were prepared with 500 mg/L and 750 mg/L concentrations for each varieties of Garcinia extract. Conventional ice made of potable water was used as the control. The chilled fish was evaluated for the changes in pH, volatile basic compounds, oxidative parameters and total viable counts and the results were compared with those of sensory analyses. Mackerel stored in ice, prepared with different concentrations of garcinia extracts significantly reduced the values of trimethyl amine, total volatile basic nitrogen, peroxide value, thiobarbituric acid reactive substances and total viable counts compared to conventional icing. The shelf life of fish stored in ice as indicated by the results of sensory evaluation was observed to be 15 days, 21 days and 24 days under conventional icing system, ice containing Garcinia indica extract and ice containing Garcinia cambogia extract respectively.

Acute Severe Liver Injury Related to Long-Term Garcinia cambogia Intake.

Abstract: Herbal and dietary supplements are frequently used as weight loss supplements. However, they account for 20% of drug-induced liver injury. Garcinia cambogia's (GC) active compound, hydroxycitric acid, can be found among those supplements. We report a 26-year-old woman who had been taking GC for 7 months when she presented with subacute liver failure and ultimately required a liver transplantation. This report highlights the risk of liver injury after long-term use of GC and demonstrates the importance of considering a close and prolonged monitoring of patients in a tertiary liver transplant center.

Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models.

Abstract: Objective Kidney stone formers have a high rate of stone recurrence after kidney stone removal surgery and there is no effective medication for treatment Hydroxycitric acid (HCA), which is the major component of Garcinia cambogia extract, can dissolve calcium oxalate crystals in vitro, suggesting that Garcinia cambogia could be used to treat calcium oxalate kidney stone In this study, we used the Drosophila kidney disease model to evaluate the effect of Garcinia cambogia on the prevention and removal of calcium oxalate stones in vivo Materials and methods Flies were reared in fly food containing different concentrations of GCE for one week The effect of GCE on preventing the formation of calcium oxalate stone was examined WT and v-ATPase gene RNAi knockdown flies were reared in fly food with 03% NaOx for one week, then fed different concentrations of GCE for one week The effect of GCE on the removal of calcium oxalate stone was examined Results Garcinia cambogia extract dissolves calcium oxalate crystals from Malpighian tubules in both genetic and non-genetic Drosophila kidney stone models compared to citric acid Hydroxycitric acid also directly dissolves calcium oxalate crystals in Drosophila Malpighian tubules ex vivo Conclusions Garcinia cambogia extract removes calcium oxalate kidney stones from Drosophila Malpighian tubules via directly dissolving calcium oxalate stones by HCA Our study strongly suggests that clinical-grade Garcinia cambogia extract could be used to treat patients with nephrolithiasis in the future

The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka.

Abstract: Traditional folk medicine in Sri Lanka is mostly based on plants and plant-derived products, however, many of these medicinal plant species are scientifically unexplored. Here, we evaluated the anti-inflammatory and antimicrobial potency of 28 different extracts prepared from seven popular medicinal plant species employed in Sri Lanka. The extracts were subjected to cell-based and cell-free assays of 5-lipoxygenase (5-LO), microsomal prostaglandin E2 synthase (mPGES)-1, and nitric oxide (NO) scavenging activity. Moreover, antibacterial and disinfectant activities were assessed. Characterization of secondary metabolites was achieved by gas chromatography coupled to mass spectrometric (GC-MS) analysis. n-Hexane- and dichloromethane-based extracts of Garcinia cambogia efficiently suppressed 5-LO activity in human neutrophils (IC50 = 0.92 and 1.39 µg/mL), and potently inhibited isolated human 5-LO (IC50 = 0.15 and 0.16 µg/mL) and mPGES-1 (IC50 = 0.29 and 0.49 µg/mL). Lipophilic extracts of Pothos scandens displayed potent inhibition of mPGES-1 only. A methanolic extract of Ophiorrhiza mungos caused significant NO scavenging activity. The lipophilic extracts of G. cambogia exhibited prominent antibacterial and disinfectant activities, and GC-MS analysis revealed the presence of fatty acids, sesquiterpenes and other types of secondary metabolites. Together, our results suggest the prospective utilization of G. cambogia as disinfective agent with potent anti-inflammatory properties.

Application of Phytochemical and Elemental Profiling, Chemometric Multivariate Analyses, and Biological Activities for Characterization and Discrimination of Fruits of Four Garcinia Species

Abstract: Species of Garcinia (Guttiferae) are used for flavoring curries, as a supplement, and to treat various diseases. This study describes the comparison and discrimination of Garcinia cambogia,...

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Abstract: Contact us: sciencevision@outlook.com The modern popular ideology is that plant-based products do not have adverse effects. Hence, people are fond of using herbal products of their choice to treat their own ailments or anyone else. As majority of the population are not aware of herbal toxicity concept, the use of formulated single or combined medicinal and/or nutritional plant extracts or isolated compounds to treat chronic diseases are increasingly popular due to the widespread concerns regarding the adverse effects of pharmaceutical drugs. Awareness from the scientific community to bring society to its senses regarding the safety issue of a herbal product is rare. Garcinia gummigutta (more popularly known by the synonym Garcinia cambogia in commercial preparations), belonging to the family of Clusiaceae (alt. Guttiferae) is a popularly consumed weight-loss nutraceutical. This review aims to highlight the possible adverse effects of G. cambogia. For the said purpose, 147 articles were collected from PubMed, Web of Science and Google scholar. Literature review revealed a plethora of beneficial actions. Investigational outcomes and clinical evidences hint the possible adverse effects likely to be linked with the use of G. cambogia. However, the use of G. cambogia as an anti-obesity agent is advisable as long as the therapeutic value outweighs the adverse effect.

Ocular complications of Garcinia cambogia extract diet pills: Case report.

Abstract: Background:Garcinia cambogia contains hydroxycitric acid. Hydroxycitric acid is a potent competitive inhibitor of adenosine triphosphate citrate lyase which is a key enzyme in the synthesis of fatt...

Identification of the volatile bioactive compounds by GC-MS analysis from the leaf extracts of Garcinia cambogia and Garcinia Indica

Abstract: Natural compounds originally derived from plants are historically considered a useful source of potential therapeutic agents, and are known to play essential roles in human diseases. The aim of the current study was to investigate the presence of bioactive compounds in hexane and methanol extracts of Garcinia cambogia and G. indica plant leaves. Both plant leaves were collected, shade dried, made into fine powder and extracted with organic solvents using Soxhlet extractor. The extracts were then analysed for the presence of phytochemicals by gas chromatography-mass spectrometry (GC-MS). The mass spectrum of the chromatography was matched with NIST and WILEY libraries. The GC-MS analysis revealed the presence of 11 and 17 bioactive compounds from the hexane and methanol extracts of G. cambogia respectively. Likewise, G. indica showed 14 compounds each from hexane and methanol extracts. The potent medicinal property within the plant extracts is due to the secondary metabolites present in the plant, which are identified by GCMS. The present investigation revealed preliminary information on bioactive components present in G. cambogia and G. indica leaf extracts, which can open a big platform for pharmacological companies to formulate various drugs from Garcinia species.

Rapid and cost-effective LC-MS/MS method for determination of hydroxycitric acid in plasma: Application in the determination of pharmacokinetics in commercial Garcinia preparations.

Abstract: Garcinia cambogia is one of the most commonly used anti-obesity dietary supplements, and hydroxycitric acid (HCA) is a major constituent in the commercial preparations of Garcinia. High doses of HCA are often consumed without much awareness of its pharmacokinetic and toxicokinetic parameters, and therefore, a complete understanding of its effects is lacking. The first step in understanding these parameters is the availability of a reliable bioanalytical method. Here, we present the first report on a UPLC-MS/MS method for analysis of HCA in rat plasma after a simplified and cost-effective protein precipitation. Chromatographic separation of the analytes in the supernatant was achieved using hydrophilic interaction liquid chromatography, where mass parameters were optimized and a rapid 5-min quantitative assay was developed. The method was highly sensitive, accurate, precise and linear in the concentration range of 10.5-5000 ng/mL (validated according to the United States Food and Drug Administration guidelines). Further, the method was successfully used to describe the pharmacokinetic profile of HCA in rat plasma after the administration of pure HCA and commercial Garcinia preparations.

Detection and quantification of active pharmaceutical ingredients as adulterants in Garcinia cambogia slimming preparations using NIR spectroscopy combined with chemometrics

Abstract: A rapid, simple and efficient method with minimal sample treatment was developed for authentication of Garcinia cambogia fruit peel powder, along with determining undeclared active pharmaceutical ingredients (APIs) in its herbal slimming dietary supplements using near infrared spectroscopy combined with chemometrics. Five featured adulterants, including sibutramine, metformin, orlistat, ephedrine, and theophylline are selected as target compounds. The Near infrared spectral data matrix of authentic Garcinia cambogia fruit peel and specimens degraded by intentional contamination with the five selected APIs was subjected to hierarchical clustering analysis to investigate their bundling figure. SIMCA models were established to ensure the genuiness of Garcinia cambogia fruit peel which resulted in perfect classification of all tested specimens. Adulterated samples were utilized for construction of PLSR models based on different APIs contents at minute levels of fraud practices (LOQ < 0.2% w/w).The suggested approach can be applied to enhance and guarantee the safety and quality of Garcinia fruit peel powder as raw material and in dietary supplements.

Effect of Garcinia Cambogia and Green Coffee Bean in Weight Reduction

Abstract: 1. Arshad Chohan Obstetrics and Gynaecology, Craft Institute of Reproduction and Fertility Treatment, Lahore marshadchohan@hotmail.com 2. Tayyiba Wasim Obstetrics and Gynaecology, Services Hospital Lahore, Lahore tayyibawasim@yahoo.com 3. Shahid Irshad Rao Obstetrics and Gynaecology, Nishter Hospital and Medical University, Multan drshahidrao@hotmail.com 4. Jahan Ara Hassan Internal Medicine, Dow University of Health Sciences, Karachi jahanaraainuddin@yahoo.com 5. Nasira Tasneem Obstetrics and Gynaecology, Pakistan Institute of Medical Sciences, Islamabad mchunit2@gmail.com 6. Tasnim Z. Ali Nutrition, Wilcare Medical Center, Lahore rdn.wilcare@gmail.com 7. Faizan Shaukat Jinnah Post Graduate Medical Center, Karachi Faizan.shaukat89@gmail.com Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 21 October 2020 doi:10.20944/preprints202010.0445.v1

Statistical Design of Sustained-Release Tablet Garcinia cambogia Extract and Bioconverted Mulberry Leaf Extract for Anti-Obesity

Abstract: Obesity is a major health concern worldwide, and it is leading to worsening disease morbidity and mortality. Herbal supplements and diet-based therapies have attracted interest in the treatment of obesity. It is known that Garcinia cambogia (GA) and mulberry leaf, which contain polyphenols, have anti-obesity activity. Herein, we developed a combined tablet consisting of GA extract and bioconverted mulberry leaf extract (BMUL) using a statistical design approach. The ratio and amount of sustained polymers were set as factors. In the cell study, the combination of GA and BMUL showed synergistic anti-obesity activity. In a statistical model, the optimized amounts of hydroxypropyl methylcellulose 2208 (HPMC 2208) and polyethylene oxide 303 (POLYOX 303) were 41.02% and 58.98%, respectively. Additionally, the selected ratio of microcrystalline cellulose (MCC) was 0.33. When the release, hardness, and friability of the GABMUL tablet were evaluated, the error percentages of the response were lower than 10%. This indicates that the GABMUL tablet was successfully prepared.

Health functional food composition for prevention of diabetes

Abstract: The present invention relates to a health functional food composition for preventing diabetes which contains: (A) oat dietary fiber; (b) a Garcinia cambogia extract powder; (c) lyophilized yacon; (D) dry yeast; (E) chicory fibers; (F) spirulina; and (G) 12 kinds of alpha mixed lactobacillus to provide effects of alleviating blood cholesterol levels, suppressing postprandial blood sugar elevation, and reducing body fat.

Age features of ultrastructure of biomineral of hip bone in white rats after excessive palm oil intake and administration of Garcinia cambogia extract

Abstract: Objective: Analysis of ultrastructure of a biomineral of hip bones (HB) in white rats in alimentary obesity caused by excessive refined palm oil (PO) intake as well as developing a method for correction of detected changes using Garcinia cambogia extract (GCE).Methods: 216 male rats (juvenile, pubertal, and senile) were used. Animals received PO at a dose of 30 g/kg a day and GCE at a dose of 0.25 g/kg a day 6 weeks later after the start of PO intake. The ultrastructure of PO biomineral was analyzed by X-ray scattering technique.Results: When juvenile rats took PO, the sizes of crystallites were 4.35% larger than control figures by the 60th day, and coefficient of micro-texturing was 4.72% lower. In pubertal rats, these deviations were 6.14 and 5.05%; in senile rats, they were 5.68 and 7.43%, respectively. When administrating GCE, in juvenile rats, the sizes of crystallites were 3.82% lower than values of group without correction by the 60th day, and coefficient of micro-texturing was 4.67% higher. In pubertal rats, these deviations accounted for 5.52 and 8.03%; and in senile rats, they were 4.34 and 5.56%, respectively.Conclusion: Consumption of PO at a dose of 30 g/kg a day is accompanied by destabilization of HP biomineral in white rats. Administration of GCE at a dose of 0.25 g/kg a day reduces the effect of PO on the ultrastructure of HB biomineral from 30 to 60 days in juvenile and pubertal rats, in senile rats – from the 60th day.

Autoimmune psychosis in Taiwan: A case report and review of literature.

Abstract: a Department of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan b Division of Psychiatry, Department of Internal Medicine, China Medical University Beigang Hospital, Yunlin, Taiwan c Department of Neurology, China Medical University Hospital, Taichung, Taiwan d Tainan Municipal An-Nan Hospital, China Medical University, Tainan, Taiwan e College of Medicine, China Medical University, Taichung, Taiwan

Toxicological potential and chemical and phytochemical characterization of garcínia cambogia.

Abstract: The use of medicinal plants for the treatment, cure and prevention of the disease is an ancient practice of mankind. Among the current ones, obesity is highlighted as a global public health problem in developed and developing countries. The study aims to outline the toxicological potential, as well as to evaluate the physicochemical and phytochemical characterization of Garcinia cambogia, in order to contribute to the safe use of this plant. They were hemoenergetic, phytochemical and toxicological, aiming to characterize the quality and safety of extracts obtained from Garcinia cambogia. It was observed that the content of foreign material, pH, total ash and acid insoluble ash were within the established limits. The values for humidity were higher than allowed. Phytochemical screening showed negative results for flavonoids and tannins, and a positive result for saponins. For the in vivo acute toxicity test the extract was categorized as "category 5" (2000 to 2500 mg / kg), and the acute lethal toxicity – LD50% estimated at 2500 mg / kg, was considered to be non-toxic. In the evaluation of the systemic toxicity no significant differences were observed between the animals of the test group and those of the control group. No macroscopic changes were observed in the organs after 14 days of experiment, demonstrating absence of acute toxicity. With the results obtained it was possible to contribute to a more detailed knowledge of Garcinia cambogia, with the more detailed information of its toxicological potential.

Effect of Garcinia Cambogia as Weight Reducing Agents on the Morphology of Liver of Albino Mice in Pakistan

Abstract: Background: Obesity is growing continuously, and people opt for pharmacological therapies, which might have negative side effects. Objective: To study the effect of Garcinia Cambogia on body weight and safety profile regarding the morphology of the liver in albino mice. Methodology: This animal experimental study was conducted on, Ninety male albino mice were used by diving into three groups containing thirty mice each. Group I, was Control group, group II and III were experimental groups, given drugs A (Slim Smart) and B (Ultra Slim Plus) respectively via oral gavage. Each group was further subdivided into subgroups "a", drug was given for 4 weeks, and "b", the drug was given for 8 weeks. Control group animals were given plain distilled water via oral gavage tube. Body weight and weight of the liver was measured and its gross features were observed. Results: Mean body weight of animals significantly increased in intervention groups, at 4 weeks, p=0.000 and 8 weeks p=0.000. Mean body weights of animals in experimental group II and III in 4 weeks categories were 33.92±3.23 grams in group II and 28.46±3.53 grams in group III. The mean relative tissue weight index at 4 weeks for group II was 6.66±0.67 and for group III was 5.71±0.41, p=0.004, while at 8 weeks were 5.88±0.64 and 5.91±0.69, p=0.713, respectively. When observed at 8 weeks time, the animals of the group I had the normal color of the liver while the two experimental groups had all the animals with the abnormally pale color of liver, p=0.001. Conclusion: In this study, the herbal slimming agents, claiming to contain Garcinia Cambogia, did not reduce weight among albino mice, and are not safe for reducing weight.

Composition with auxiliary hypoglycemic effect and preparation method thereof

Abstract: The invention, which belongs to the technical field of medicines, discloses a composition with an auxiliary hypoglycemic effect and a preparation method thereof. The composition comprises components of the root of membranous milk vetch, ginseng leaves, the tuber of multiflower knotweed, the fruit of Chinese wolfberry, the root of kudzu vine, garcinia cambogia, a filling agent, high-calcium bone meal and fatty acid powder. The filling agent contains radish and paspalum conjugatum. According to the invention, because of hydroxy citric acid on the garcinia cambogia peel, conversion of glucose into fat can be hindered and conversion into liver sugar which is easily utilized as heat is promoted, so that the obesity is prevented and thus the patient can not keep the fit after the blood glucose increases; the radish and paspalum conjugatum have effects of clearing away heat and toxic materials and resisting bacteria, so that a problem that patients feel uncomfortable is solved, nutrition imbalance of the patients is effectively adjusted, a phenomenon that the weight of the patient can not be kept is avoided, and the in-vivo environment of the patient can be protected from being damaged due to the too high blood sugar; and all organs are protected from being influenced.

Diet rice and its manufacturing method

Abstract: The present invention relates to rice for diet management, comprising 20 to 30 parts by weight of a fermentation liquid consisting of a beneficial bacteria combination including lactic acid bacteria, 3 to 5 parts by weight of Garcinia cambogia peel extract (HCA), and 10 to 15 parts by weight of grapefruit extract, wherein the surface of the rice is coated with HCA, the beneficial bacteria combination includes two or more lactic acid bacteria, yeast and Aspergillus oryzae, the rice is brown rice or 50%-dehusked rice with induced germination, and the germination takes place for 24 to 40 hours at a temperature of 18 to 32°C.

A composition for lipolysis

Abstract: According to the present specification, disclosed is a composition for fat decomposition, including a natural product mixture extract as an active ingredient together with a fat decomposition component The natural product mixture extract further improves fat-decomposition efficacy of a fat-decomposition component by including a plum extract, a lonicera japonica extract, a scutellaria baicalensis root extract, a melissa officinalis extract, a garcinia cambogia extract, a puer tea extract, and a wide mango extract