Institution
Pakistan Institute of Medical Sciences
Healthcare•Islamabad, Pakistan•
About: Pakistan Institute of Medical Sciences is a healthcare organization based out in Islamabad, Pakistan. It is known for research contribution in the topics: Population & Medicine. The organization has 619 authors who have published 654 publications receiving 9965 citations.
Papers published on a yearly basis
Papers
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TL;DR: This review discusses recent relevant reports on deaths occurring in hospital during or within 30 days of a surgical procedure and identifies patterns of practice, service provision and public health issues that may contribute to a poor outcome or the death of patients.
913 citations
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TL;DR: A novel mitochondrial protein, Twinkle, with structural similarity to phage T7 gene 4 primase/helicase and other hexameric ring helicases is reported, inferred to be critical for lifetime maintenance of human mtDNA integrity.
Abstract: The gene products involved in mammalian mitochondrial DNA (mtDNA) maintenance and organization remain largely unknown. We report here a novel mitochondrial protein, Twinkle, with structural similarity to phage T7 gene 4 primase/helicase and other hexameric ring helicases. Twinkle colocalizes with mtDNA in mitochondrial nucleoids. Screening of the gene encoding Twinkle in individuals with autosomal dominant progressive external ophthalmoplegia (adPEO), associated with multiple mtDNA deletions, identified 11 different coding-region mutations co-segregating with the disorder in 12 adPEO pedigrees of various ethnic origins. The mutations cluster in a region of the protein proposed to be involved in subunit interactions. The function of Twinkle is inferred to be critical for lifetime maintenance of human mtDNA integrity.
844 citations
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UNICEF1, Khon Kaen University2, University of Nairobi3, University of Ibadan4, Makerere University5, Abdou Moumouni University6, Peking University7, Pakistan Institute of Medical Sciences8, Government of Nepal9, Indian Council of Medical Research10, Pokhara University11, Chulalongkorn University12, University of Tokyo13, American University of Beirut14, State University of Campinas15, Institute for Health Metrics and Evaluation16, Inter-American Development Bank17, National Autonomous University of Nicaragua18, Dalhousie University19, University of Adelaide20, Emory University21, Uppsala University22, All India Institute of Medical Sciences23, University of Pretoria24, United States Agency for International Development25
TL;DR: High coverage of essential interventions did not imply reduced maternal mortality in the health-care facilities the authors studied, and the maternal severity index (MSI) had good accuracy for maternal death prediction in women with markers of organ dysfunction.
533 citations
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TL;DR: Five mutations in the maternal gene NALP7 in individuals with familial and recurrent HMs are reported, which is the first maternal effect gene identified in humans and is also responsible for recurrent spontaneous abortions, stillbirths and intrauterine growth retardation.
Abstract: Hydatidiform mole (HM) is an abnormal human pregnancy with no embryo and cystic degeneration of placental villi. We report five mutations in the maternal gene NALP7 in individuals with familial and recurrent HMs. NALP7 is a member of the CATERPILLER protein family involved in inflammation and apoptosis. NALP7 is the first maternal effect gene identified in humans and is also responsible for recurrent spontaneous abortions, stillbirths and intrauterine growth retardation.
412 citations
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TL;DR: This poster presents a probabilistic analysis of the immune system’s response to diarrhoea and reveals clear patterns of decline in the immune systems of immune-inflammatory bowel disease and central nervous system disorders.
344 citations
Authors
Showing all 619 results
Name | H-index | Papers | Citations |
---|---|---|---|
Timothy R. Walsh | 77 | 305 | 30554 |
Michael S. Marber | 62 | 289 | 13142 |
Sheikh Riazuddin | 58 | 259 | 10934 |
José Guilherme Cecatti | 56 | 414 | 10550 |
Muhammad Zubair | 51 | 806 | 10265 |
Saima Riazuddin | 47 | 137 | 7387 |
Umar Farooq | 39 | 510 | 9889 |
Mobeen H. Rathore | 37 | 201 | 5913 |
Shamim Qazi | 36 | 163 | 5721 |
Javed Akram | 24 | 89 | 1780 |
Mushtaq Khan | 23 | 119 | 1567 |
Tabish Hazir | 20 | 38 | 1596 |
Yasir Bin Nisar | 15 | 27 | 839 |
Mohsin Shahzad | 15 | 36 | 835 |
Muhammad Saaiq | 14 | 55 | 607 |