S
Simone I. Strasser
Researcher at Royal Prince Alfred Hospital
Publications - 245
Citations - 9419
Simone I. Strasser is an academic researcher from Royal Prince Alfred Hospital. The author has contributed to research in topics: Liver transplantation & Transplantation. The author has an hindex of 40, co-authored 214 publications receiving 7431 citations. Previous affiliations of Simone I. Strasser include University of Washington & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial.
Andrew X. Zhu,Richard S. Finn,Julien Edeline,Stéphane Cattan,Sadahisa Ogasawara,Daniel H. Palmer,Chris Verslype,Vittorina Zagonel,Laetitia Fartoux,Arndt Vogel,Debashis Sarker,Gontran Verset,Stephen L. Chan,Jennifer J. Knox,Bruno Daniele,Andrea L. Webber,Scot Ebbinghaus,Junshui Ma,Abby B. Siegel,Ann-Lii Cheng,Masatoshi Kudo,Angela Tatiana Alistar,Jamil Asselah,Jean-Frédéric Blanc,Ivan Borbath,Timothy Cannon,Ki Chung,Allen Lee Cohn,David Cosgrove,Nevena Damjanov,Mukul Gupta,Yoshivasu Karino,Mark Karwal,Andreas Kaubisch,Robin Kate Kelley,Jena-Luc Van Laethem,Timothy Larson,James Lee,Daneng Li,Atisha Manhas,Gulam Abbas Manji,Kazushi Numata,Benjamin M. Parsons,Andrew Scott Paulson,Carmine Pinto,Robert A. Ramirez,Suresh Ratnam,Magnus Rizell,Olivier Rosmorduc,Yvonne Sada,Yutaka Sasaki,Per I Stal,Simone I. Strasser,Joerg Trojan,Gina M. Vaccaro,Hans Van Vlierberghe,Alan Weiss,Karl-Heinz Weiss,Tatsuya Yamashita +58 more
TL;DR: Pembrolizumab was effective and tolerable in patients with advanced hepatocellular carcinoma who had previously been treated with sorafenib and is undergoing further assessment in two phase 3, randomised trials as a second-line treatment.
Journal ArticleDOI
A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis
Frederik Nevens,Pietro Andreone,Giuseppe Mazzella,Simone I. Strasser,Christopher L. Bowlus,Pietro Invernizzi,J.P.H. Drenth,Paul J. Pockros,Jaroslaw Regula,Ulrich Beuers,Michael Trauner,David Jones,Annarosa Floreani,Simon Hohenester,Velimir A. Luketic,Mitchell L. Shiffman,K.J. van Erpecum,Victor Vargas,Catherine Vincent,Gideon M. Hirschfield,Hemant Shah,Bettina E. Hansen,Keith D. Lindor,Hanns-Ulrich Marschall,Kris V. Kowdley,R. Hooshmand-Rad,T. Marmon,S. Sheeron,R. Pencek,Leigh MacConell,Mark Pruzanski,David Shapiro +31 more
TL;DR: Obeticholic acid administered with ursodiol or as monotherapy for 12 months in patients with primary biliary cholangitis resulted in decreases from baseline in alkaline phosphatase and total bilirubin levels that differed significantly from the changes observed with placebo.
Journal ArticleDOI
Sofosbuvir, velpatasvir, and voxilaprevir for previously treated HCV infection
Marc Bourlière,Stuart C. Gordon,Steven L. Flamm,Curtis Cooper,Alnoor Ramji,Myron J. Tong,Natarajan Ravendhran,John M. Vierling,Tram T. Tran,S. Pianko,Meena B. Bansal,Victor de Ledinghen,Robert H. Hyland,Luisa M. Stamm,Hadas Dvory-Sobol,Evguenia S. Svarovskaia,Jie Zhang,K.C. Huang,G. Mani Subramanian,Diana M. Brainard,John G. McHutchison,Elizabeth C. Verna,Peter Buggisch,Charles S. Landis,Ziad Younes,Michael P. Curry,Simone I. Strasser,Eugene R. Schiff,K. Rajender Reddy,Michael P. Manns,Kris V. Kowdley,Stefan Zeuzem +31 more
TL;DR: Sofosbuvir‐velpatasvir‐voxilaprevir taken for 12 weeks provided high rates of sustained virologic response among patients across HCV genotypes in whom treatment with a DAA regimen had previously failed.
Journal ArticleDOI
Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial
Edward K. Geissler,Andreas A. Schnitzbauer,Andreas A. Schnitzbauer,Carl Zülke,P. Lamby,Andrea Proneth,Christophe Duvoux,Patrizia Burra,Karl-Walter Jauch,Markus Rentsch,Tom M. Ganten,Jan Schmidt,Utz Settmacher,Michael Heise,Michael Heise,Giorgio Rossi,Umberto Cillo,Norman M. Kneteman,René Adam,Bart van Hoek,Philippe Bachellier,Philippe Wolf,Lionel Rostaing,Wolf O. Bechstein,Magnus Rizell,James J. Powell,Ernest Hidalgo,J. Gugenheim,Heiner Wolters,Jens Brockmann,André Roy,Ingrid Mutzbauer,Angela Schlitt,Susanne Beckebaum,Christian Graeb,Silvio Nadalin,Umberto Valente,Victor Sanchez Turrion,Neville V. Jamieson,T. Scholz,Michele Colledan,Fred Fändrich,Thomas Becker,Gunnar Söderdahl,Olivier Chazouillères,Heikki Mäkisalo,Georges-Philippe Pageaux,Rudolf Steininger,Thomas Soliman,Koert P. de Jong,Jacques Pirenne,Raimund Margreiter,Johann Pratschke,Antonio Daniele Pinna,Johann Hauss,Stefan Schreiber,Simone I. Strasser,Jürgen Klempnauer,Roberto Troisi,Sherrie Bhoori,Jan Lerut,Itxarone Bilbao,Christian Klein,Alfred Königsrainer,Darius F. Mirza,Gerd Otto,Vincenzo Mazzaferro,Peter Neuhaus,Hans J. Schlitt +68 more
TL;DR: This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with HCC and reveals that low-risk, rather than high- risk, patients benefited most from sirolimus; furthermore, younger recipients (age ⩽60) also benefited, as well siro Limus monotherapy patients.
Journal ArticleDOI
Combination of Tenofovir Disoproxil Fumarate and Peginterferon α-2a Increases Loss of Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B
Patrick Marcellin,Sang Hoon Ahn,Xiaoli Ma,Florin Alexandru Caruntu,Won Young Tak,Magdy Elkashab,Wan-Long Chuang,Seng Gee Lim,Fehmi Tabak,R. Mehta,Joerg Petersen,Graham R. Foster,Lillian Lou,Eduardo B. Martins,Phillip Dinh,Lanjia Lin,Amoreena Corsa,Prista Charuworn,G. Mani Subramanian,Hans Reiser,Hendrick W. Reesink,Scott Fung,Simone I. Strasser,Huy N. Trinh,Maria Buti,Giovanni Battista Gaeta,Aric J. Hui,George V. Papatheodoridis,Robert Flisiak,Henry Lik-Yuen Chan +29 more
TL;DR: A significantly greater proportion of patients received TDF plus peginterferon for 48 weeks had HBsAg loss than those receiving TDF or peginerferon alone.