Showing papers on "Radiation-induced lung injury published in 2007"

Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury

Abstract: Purpose: Remodeling of extracellular matrix (ECM) after lung damage depends on collagen degrading Matrix-Metallo-Proteinases (MMP) and their endogenous inhibitors (Tissue-Inhibitors of Metallo-Proteinases, TIMP). Transforming growth factor (TGF)-β1 has been implicated in the pathogenesis of radiation-induced lung fibrosis upon its effects on fibroblast proliferation and collagen synthesis. Lung cancer patients have often elevated TGF-β1 plasma levels as a result of increased TGF-β1 expression in their tumours. On this background, we investigated the effect of irradiation on the MMP/TIMP system in the lung tissue of normal and transgenic TGF-β1 mice, in which TGF-β1 is overexpressed in the liver resulting in high TGF-β1 plasma levels.Material and methods: Transgenic (TG) and wild-type (WT) mice underwent thoracic irradiation with 12 Gy or sham-irradiation. For each study group (TG 12 Gy; TG 0 Gy; WT 12 Gy; WT 0 Gy) 8 mice were sacrificed at 4 and 8 weeks after (sham-) irradiation. The TGF-β1, TIMP-1/-2/-3 ...

Changes in Expression of Injury After Irradiation of Increasing Volumes in Rat Lung

Abstract: Purpose: To improve the cure rates of thoracic malignancies by radiation dose escalation, very accurate insight is required in the dose delivery parameters that maximally spare normal lung function. Radiation-induced lung complications are classically divided into an early pneumonitic and a late fibrotic phase. This study investigated the relative dose–volume sensitivity, underlying pathologic findings, and consequentiality of early to late pathologic features. Methods and Materials: We used high-precision, graded dose–volume lung irradiations and followed the time dependency of the morphologic sequelae in relation to overall respiratory function. Results: Two distinct pathologic lesions were identified in the early postirradiation period (6–12 weeks): vascular inflammation and parenchymal inflammation. Vascular inflammation occurred at single doses as low as 9 Gy. This translated into early respiratory dysfunction only when a large lung volume had been irradiated and was reversible with time. Parenchymal inflammation was seen after higher doses only (onset at 16 Gy), progressed into later fibrotic remodeling but did not translate into dysfunction at a 25% lung volume even after single doses up to 36 Gy. Conclusion: Our data imply that a low dose scattered over a large lung volume causes more early toxicity than an extreme dose confined to a small volume. Such findings are crucial for clinical treatment planning of dose escalations and choices for modern radiotherapy techniques.

[Effects of blood-cooling and promoting drugs on rats with radiation-induced lung injury].

Abstract: Objective To investigate the effect of blood-cooling and promoting drugs (BCPD) on the dy-namic changes of collagens and the expressions of interleukin-6 (IL-6) and transforming growth factor beta (TGF-beta) in lung tissue of rats with radiation-induced lung injury (RILI) to explore the effects and action mech-anism of BCPD in preventing and treating RILI. Methods One hundred and sixty Wistar female rats were ran-domly divided into the radiation group, the treatment group, the blank control group and the drug control group. The rats in the first two groups received right hemithoracic fractionated radiation, and those in the treatment group were given BCPD. Rats in the other two groups were not irradiated and BCPD was given to rats in the drug control group. The rats were sacrificed in batches (8 of each group in every batch) at the 3rd, 5th, 8th, 12th and 26th week of the experimental period, and their lung was taken for observing the dynamic changes and distribution of collagen and the expressions of IL-6 and TGF-beta with HE staining, picrosirius red staining and immunohistochemical staining respectively. Results The fibroblast proliferated obviously from the 3rd week after the first radiation in the radiation group, and the type I collagen and the proportion of type I and III collagen were significantly elevated along the time going and the radiation dose increasing, became significantly higher than those in the treatment group at all the time points (P Conclusion BCPD applied in the early stage of radiation can suppress the inflammatory and fibrogenic cytokine expressions, inhibit the synthesis of collagens and adjust the proportion of type I and III collagen, so as to re-lieve the early-stage inflammatory reaction and the anaphase lung fibrosis in RILI rats.

Relationship between the Plasma Transforming Growth Factor-β1 Levels and Radiation-Induced Lung Injury

Abstract: Objective To investigate the relationship between the pre-and posttreatment plasma TGF-β1 levels,V20 and radiation-induced lung injuryMethods Fifty-three patients with lung cancer receiving 3DCRT were included in this studyThe radiation was delivered in 2Gy per fraction,5 fractions per weeks,with a total dose from 40 to 70GyThe percentage of both lung volume receiving 20Gy or more(V20) was restricted to 35% or less,and dose to the spinal cord was restricted to 45GyConcentrations of pre-and posttreatment plasma TGF-β1 were quantified byELISAResults The radiation induced lung injury was noted in 357%(17/53)patients,and 132% patients developped Grade 2 or worse radiation-induced lung injuryThe incidence of the radiation induced lung injury was 519 % in patients with elevated posttreatment TGF-β1 levels,and this was significantly higher than those with normal TGF-β1 levels(115%)(P=0002)The pre-treatment TGF-β1 levels had no correlation with radiation-induced lung injury(P=0315)The radiation-induced lung injury developped in 625% patients with V2025% and elevated post-treatment TGF-β1 levels,and this was significantly higher than those of other groupsNone of the patients with V20≤25% and normal post-treatment TGF-β1 levels developped radiation-induced lung injuryConclusion Radiation-induced lung injury is related to the plasma TGF-β1 levels at the end of radiationPatients with V2025% and elevated posttreatment TGF-β1 levels are at especially high risk to develop radiation induced lung injury

The combined therapy of radiation induced lung injury

Abstract: 目的 探讨放射性肺损伤综合治疗的新观点和疗效.方法 将86例放疗后6个月内发生放射性肺损伤的患者分成两组,一组给予常规西药治疗(西药组,56例),一组行西药、中药、生理、心理治疗及灵性照顾的综合治疗(综合组,30例),比较两组患者在临床症状及CT表现方面的差异.结果 在临床症状改善方面综合组比西药组效果好,但差异无统计学意义(P＞0.05).CT表现方面综合组Ⅰ型(片状渗出型)和Ⅱ型(补丁实变型)的有效率为94%,明显优于西药组的57%(P＜0.05).结论 综合治疗疗效优于常规西药治疗,特别是Ⅰ、Ⅱ型早期放射性肺炎病例。

Evaluation of radiation-induced lung injury in rabbit with multislice spiral CT

Abstract: Objective To evaluate the application value of multislice spiral CT(MSCT) in rabbits with radiation-induced lung injury.Methods Forty rabbits were divided into the normal control groups and experimental groups randomly,and the latter groups received a single dose of 50Gy to the right lung.MSCT images were obtained on the 3rd,5th,7th,8th,11th,14th day,and 3rd,5th,8th and 12th week,pulmonary density of both right and left lung were assessed with pulmo of automatic evaluation software.Results The MSCT images of rabbits were normal in two weeks,while analysized by pulmo of automatic evaluation software,it was shown that the density of right lungs were higher than that of left lung after the 7th day(P0.05).Various CT findings including ground-glass opacity,patchy consolidation and high density fibrosis were observed at the scheduled study.Conclusion It plays an important role for MSCT to diagnose radiation-induced lung injury,and the early diagnosis radiation-induced lung injury can be done with pulmo of automatic evaluation software.