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Sarah A. Smith
Researcher at University of Pennsylvania
Publications - 9
Citations - 1912
Sarah A. Smith is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: RNA & Gut flora. The author has an hindex of 7, co-authored 9 publications receiving 1563 citations.
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Journal ArticleDOI
A compendium of RNA-binding motifs for decoding gene regulation
Debashish Ray,Hilal Kazan,Kate B. Cook,Matthew T. Weirauch,Matthew T. Weirauch,Hamed S. Najafabadi,Xiao Li,Serge Gueroussov,Mihai Albu,Hong Zheng,Ally Yang,Hong Na,Manuel Irimia,Leah H. Matzat,Ryan K. Dale,Sarah A. Smith,Christopher A. Yarosh,Seth M. Kelly,Behnam Nabet,D. Mecenas,Weimin Li,Rakesh S. Laishram,Mei Qiao,Howard D. Lipshitz,Fabio Piano,Anita H. Corbett,Russ P. Carstens,Brendan J. Frey,Richard A. Anderson,Kristen W. Lynch,Luiz O. F. Penalva,Elissa P. Lei,Andrew G. Fraser,Benjamin J. Blencowe,Quaid Morris,Timothy P. Hughes +35 more
TL;DR: A systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24 diverse eukaryotes, provides an unprecedented overview of RNA- binding proteins and their targets, and constitute an invaluable resource for determining post-transcriptional regulatory mechanisms in eukARYotes.
Journal ArticleDOI
Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production
Gary D. Wu,Charlene Compher,Eric Z. Chen,Sarah A. Smith,Rachana Shah,Kyle Bittinger,Christel Chehoud,Lindsey Albenberg,Lisa Nessel,Erin Gilroy,Julie Star,Aalim M. Weljie,Harry J. Flint,David C. Metz,Michael J. Bennett,Hongzhe Li,Frederic D. Bushman,James D. Lewis +17 more
TL;DR: High consumption of fermentable substrate in vegans was not associated with higher levels of faecal short chain fatty acids, a finding confirmed in a 10-day controlled feeding experiment, and residence in globally distinct societies helps determine the composition of the gut microbiota that influences the production of diet-dependent gut microbial metabolites.
Journal ArticleDOI
hnRNP U Enhances Caspase-9 Splicing and Is Modulated by AKT-dependent Phosphorylation of hnRNP L
Ngoc T. Vu,Margaret A. Park,Jacqueline C. Shultz,Rachel W. Goehe,L. Alexis Hoeferlin,Michael D. Shultz,Sarah A. Smith,Kristen W. Lynch,Charles E. Chalfant,Charles E. Chalfant +9 more
TL;DR: HnRNP U promotes the exon cassette inclusion to form caspase-9a and the results demonstrate the importance of the phosphoinositide 3-kinase/AKT pathway in modulating the association of hnR NP U to C9/E3.
Journal ArticleDOI
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines.
Sarah A. Smith,Sayaka A. Ogawa,Lillian Chau,Kelly A. Whelan,Kathryn E. Hamilton,Jie Chen,Lu Tan,Eric Z. Chen,Eric Z. Chen,Sue A. Keilbaugh,Franz Fogt,Meenakshi Bewtra,Jonathan Braun,Ramnik J. Xavier,Ramnik J. Xavier,Clary B. Clish,Barry Slaff,Aalim M. Weljie,Frederic D. Bushman,James D. Lewis,Hongzhe Li,Stephen R. Master,Michael J. Bennett,Michael J. Bennett,Hiroshi Nakagawa,Gary D. Wu +25 more
TL;DR: It is shown that the intestinal epithelium can also oxidize long-chain fatty acids, and that luminally-delivered acylcarnitines in bile can be consumed via apical absorption by the intestinal tissue resulting in mitochondrial oxidation.
Journal ArticleDOI
Paralogs hnRNP L and hnRNP LL Exhibit Overlapping but Distinct RNA Binding Constraints
Sarah A. Smith,Debashish Ray,Kate B. Cook,Michael J. Mallory,Timothy P. Hughes,Kristen W. Lynch +5 more
TL;DR: It is suggested that overlapping but divergent RNA-binding preferences, as it is shown here for hnRNP L and hmRNP LL, may be commonplace among other hn RNP paralogs.