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Aarron T. Willingham
Researcher at Merck & Co.
Publications - 35
Citations - 7445
Aarron T. Willingham is an academic researcher from Merck & Co.. The author has contributed to research in topics: RNA & Genome. The author has an hindex of 20, co-authored 34 publications receiving 6889 citations. Previous affiliations of Aarron T. Willingham include University of California, San Diego & Sirna Therapeutics.
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Journal ArticleDOI
RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
Philipp Kapranov,Jill Cheng,Sujit Dike,David A. Nix,Radharani Duttagupta,Aarron T. Willingham,Peter F. Stadler,Jana Hertel,Jörg Hackermüller,Ivo L. Hofacker,Ian Bell,Evelyn Cheung,Jorg Drenkow,Erica Dumais,Sandeep Patel,Gregg Helt,Madhavan Ganesh,Srinka Ghosh,Antonio Piccolboni,Victor Sementchenko,Hari Tammana,Thomas R. Gingeras +21 more
TL;DR: Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes and support a highly interleaved organization of the human transcriptome.
Journal ArticleDOI
The developmental transcriptome of Drosophila melanogaster
Brenton R. Graveley,Angela N. Brooks,Joseph W. Carlson,Michael O. Duff,Jane M. Landolin,Li Yang,Carlo G. Artieri,Marijke J. van Baren,Nathan Boley,Benjamin W. Booth,James B. Brown,Lucy Cherbas,Carrie A. Davis,Alexander Dobin,Renhua Li,Wei Lin,John H. Malone,Nicolas R. Mattiuzzo,David Scott Miller,David Sturgill,Brian B. Tuch,Brian B. Tuch,Chris Zaleski,Dayu Zhang,Marco Blanchette,Marco Blanchette,Sandrine Dudoit,Brian D. Eads,Richard E. Green,Ann S. Hammonds,Lichun Jiang,Phil Kapranov,Laura Langton,Norbert Perrimon,Jeremy E. Sandler,Kenneth H. Wan,Aarron T. Willingham,Yu Zhang,Yi Zou,Justen Andrews,Peter J. Bickel,Steven E. Brenner,Michael R. Brent,Peter Cherbas,Thomas R. Gingeras,Thomas R. Gingeras,Roger A. Hoskins,Thomas C. Kaufman,Brian Oliver,Susan E. Celniker +49 more
TL;DR: 111,195 new elements are identified, including thousands of genes, coding and non-coding transcripts, exons, splicing and editing events and inferred protein isoforms that previously eluded discovery using established experimental, prediction and conservation-based approaches.
Journal ArticleDOI
A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.
Aarron T. Willingham,Anthony P. Orth,Serge Batalov,Eric C. Peters,Ben Wen,Pedro Aza-Blanc,John B. Hogenesch,Peter G. Schultz,Peter G. Schultz +8 more
TL;DR: An ncRNA repressor of the nuclear factor of activated T cells (NFAT), which interacts with multiple proteins including members of the importin-beta superfamily and likely functions as a specific regulator of NFAT nuclear trafficking is identified.
Journal ArticleDOI
Genome-wide transcription and the implications for genomic organization.
TL;DR: Observations suggest that genomic architecture is not colinear, but is instead interleaved and modular, and that the same genomic sequences are multifunctional: that is, used for multiple independently regulated transcripts and as regulatory regions.
Journal ArticleDOI
A Drosophila Mechanosensory Transduction Channel
TL;DR: This data indicates that the no mechanoreceptor potential C (nompC) gene encodes a new ion channel that is essential for mechanosensory transduction, and D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanos Sensory organs.