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Adam Auton
Researcher at Albert Einstein College of Medicine
Publications - 109
Citations - 65100
Adam Auton is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 47, co-authored 94 publications receiving 51799 citations. Previous affiliations of Adam Auton include Broad Institute & Cornell University.
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Journal ArticleDOI
The distribution and causes of meiotic recombination in the human genome.
Simon Myers,Simon Myers,Chris C. A. Spencer,Adam Auton,Leonardo Bottolo,Colin Freeman,Peter Donnelly,Gil McVean +7 more
TL;DR: This map, which has a resolution several orders of magnitude greater than previous studies, identifies over 25,000 recombination hotspots and gives new insights into the distribution and determination of recombination, and suggests possible resolutions of the hotspot paradox.
Journal ArticleDOI
Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24
Angela M. Jones,Kimberley Howarth,Lynn Martin,Maggie Gorman,Radu Mihai,Laura Moss,Adam Auton,Catherine Lemon,Hisham Mehanna,Hosahalli Mohan,Susan E. M. Clarke,Jonathan Wadsley,Elena Macias,Andrew Coatesworth,Matthew Beasley,Tom Roques,Craig Martin,Paul Ryan,Georgina Gerrard,Danielle Power,Caroline Bremmer,Ian Tomlinson,Luis G. Carvajal-Carmona +22 more
TL;DR: In this paper, five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24), rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13).
Journal ArticleDOI
Refined genetic maps reveal sexual dimorphism in human meiotic recombination at multiple scales.
TL;DR: It is shown that, although a substantial fraction of the genome shows some degree of sexually dimorphic recombination, the vast majority of hotspots are shared between the sexes, with only a small number of putative sex-specific hotspots.
Journal ArticleDOI
Inferring human colonization history using a copying model.
TL;DR: A statistical approach that uses Single Nucleotide Polymorphism (SNP) data to identify sharing of chromosomal segments between populations and uses the pattern of sharing to reconstruct a detailed colonization scenario is introduced.
Journal ArticleDOI
Genetic Consequences of the Transatlantic Slave Trade in the Americas.
Steven J. Micheletti,Kasia Bryc,Samantha G. Ancona Esselmann,William A. Freyman,Meghan E. Moreno,G. David Poznik,Anjali J. Shastri,Michelle Agee,Stella Aslibekyan,Adam Auton,Robert K. Bell,S. Clark,Sayantan Das,Sarah L. Elson,Kipper Fletez-Brant,Pierre Fontanillas,P. Gandhi,Karl Heilbron,Barry W. Hicks,David A. Hinds,Karen E. Huber,Ethan M. Jewett,Yunxuan Jiang,Aaron Kleinman,Keng-Han Lin,Nadia Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Kimberly F. McManus,Sahar V. Mozaffari,P. Nandakumar,L. Noblin,Carrie Northover,Jeffery R. O'Connell,A. Petrakovitz,Steven J. Pitts,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,R. Tunney,Vladimir Vacic,Xin Wang,A. Zare,Sandra Beleza,Joanna L. Mountain +45 more
TL;DR: This investigation of the transatlantic slave trade is broad in scope in terms of both datasets and analyses, establishes genetic links between individuals in the Americas and populations across Atlantic Africa, yielding a more comprehensive understanding of the African roots of peoples of the Americas.