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Adam Auton
Researcher at Albert Einstein College of Medicine
Publications - 109
Citations - 65100
Adam Auton is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 47, co-authored 94 publications receiving 51799 citations. Previous affiliations of Adam Auton include Broad Institute & Cornell University.
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Journal ArticleDOI
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences
G. David Poznik,Yali Xue,Fernando L. Mendez,Thomas Willems,Andrea Massaia,Melissa A. Wilson Sayres,Qasim Ayub,Shane A. McCarthy,Apurva Narechania,Seva Kashin,Yuan Chen,Ruby Banerjee,Juan L. Rodriguez-Flores,Maria Cerezo,Haojing Shao,Melissa Gymrek,Ankit Malhotra,Sandra Louzada,Rob DeSalle,Graham R. S. Ritchie,Graham R. S. Ritchie,Eliza Cerveira,Tomas W Fitzgerald,Erik Garrison,Anthony Marcketta,David Mittelman,Mallory Romanovitch,Chengsheng Zhang,Xiangqun Zheng-Bradley,Gonçalo R. Abecasis,Steven A. McCarroll,Paul Flicek,Peter A. Underhill,Lachlan J. M. Coin,Daniel R. Zerbino,Fengtang Yang,Charles Lee,Laura Clarke,Adam Auton,Yaniv Erlich,Robert E. Handsaker,Robert E. Handsaker,Carlos Bustamante,Chris Tyler-Smith +43 more
TL;DR: A calibrated phylogenetic tree is constructed on the basis of binary single-nucleotide variants and the more complex variants onto it, estimating the number of mutations for each class and shows bursts of extreme expansion in male numbers that have occurred independently among the five continental superpopulations examined.
Journal ArticleDOI
Recombination rate estimation in the presence of hotspots
Adam Auton,Gil McVean +1 more
TL;DR: The method is used to reanalyze genetic variation data from the HLA and MS32 regions of the human genome and demonstrates that it is able to provide accurate rate estimates and simultaneously detect hotspots, a substantial improvement over a commonly used method.
Journal ArticleDOI
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.
Douglas P Wightman,Iris E. Jansen,Jeanne E. Savage,Alexey A. Shadrin,Shahram Bahrami,Shahram Bahrami,Dominic Holland,Arvid Rongve,Sigrid Børte,Sigrid Børte,Sigrid Børte,Bendik S. Winsvold,Bendik S. Winsvold,Ole Kristian Drange,Amy E Martinsen,Amy E Martinsen,Amy E Martinsen,Anne Heidi Skogholt,Cristen J. Willer,Geir Bråthen,Ingunn Bosnes,Ingunn Bosnes,Jonas B. Nielsen,Jonas B. Nielsen,Jonas B. Nielsen,Lars G. Fritsche,Laurent F. Thomas,Linda M. Pedersen,Maiken Elvestad Gabrielsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Tore Wergeland Meisingset,Wei Zhou,Wei Zhou,Petroula Proitsi,Angela Hodges,Richard Dobson,Latha Velayudhan,Karl Heilbron,Adam Auton,Julia M. Sealock,Lea K. Davis,Nancy L. Pedersen,Chandra A. Reynolds,Ida K. Karlsson,Ida K. Karlsson,Sigurdur H. Magnusson,Hreinn Stefansson,Steinunn Thordardottir,Palmi V. Jonsson,Jon Snaedal,Anna Zettergren,Ingmar Skoog,Ingmar Skoog,Silke Kern,Silke Kern,Margda Waern,Margda Waern,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Eystein Stordal,Eystein Stordal,Kristian Hveem,John-Anker Zwart,John-Anker Zwart,John-Anker Zwart,Lavinia Athanasiu,Lavinia Athanasiu,Per Selnes,Ingvild Saltvedt,Sigrid Botne Sando,Ingun Ulstein,Srdjan Djurovic,Srdjan Djurovic,Tormod Fladby,Tormod Fladby,Dag Aarsland,Dag Aarsland,Geir Selbæk,Geir Selbæk,Stephan Ripke,Stephan Ripke,Stephan Ripke,Kari Stefansson,Ole A. Andreassen,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +89 more
TL;DR: This paper identified microglia, immune cells and protein catabolism as relevant genes for late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest.
Journal ArticleDOI
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Andrea Ganna,Karin J. H. Verweij,Michel G. Nivard,Robert Maier,Robert Maier,Robbee Wedow,Alexander S Busch,Alexander S Busch,Abdel Abdellaoui,Shengru Guo,J. Fah Sathirapongsasuti,Paul Lichtenstein,Sebastian Lundström,Niklas Långström,Adam Auton,Kathleen Mullan Harris,Gary W. Beecham,Eden R. Martin,Alan R. Sanders,Alan R. Sanders,John R. B. Perry,Benjamin M. Neale,Benjamin M. Neale,Brendan P. Zietsch +23 more
TL;DR: This genome-wide association study of same-sex sexual behavior identifies loci associated with human sexual orientation that suggest links to biological pathways that involve sex hormone regulation and olfaction and investigates the biology and complexity of the trait.
Journal ArticleDOI
Genetic recombination is targeted towards gene promoter regions in dogs.
Adam Auton,Yingrui Li,Jeffrey M. Kidd,Kyle C. Oliveira,Julie Nadel,J. Kim Holloway,Jessica J. Hayward,Paula E. Cohen,John M. Greally,Jun Wang,Carlos Bustamante,Adam R. Boyko +11 more
TL;DR: A fine-scale genetic map is constructed from patterns of linkage disequilibrium assessed using high-throughput sequence data from 51 free-ranging dogs to show that biased gene conversion is a plausible mechanism by which the high CpG content of the dog genome could have occurred.