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Adam J. Funk
Researcher at University of Toledo
Publications - 23
Citations - 1808
Adam J. Funk is an academic researcher from University of Toledo. The author has contributed to research in topics: Dorsolateral prefrontal cortex & Prefrontal cortex. The author has an hindex of 12, co-authored 22 publications receiving 1606 citations. Previous affiliations of Adam J. Funk include University of Cincinnati Academic Health Center & University of Alabama at Birmingham.
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Journal ArticleDOI
Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
Journal ArticleDOI
Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia
TL;DR: Proteins and phospho-proteins comprising mitogen activated protein kinase (MAPK) and 3′–5′-cyclic adenosine monophosphate (cAMP)-associated signaling pathways may be abnormally expressed in the anterior cingulate (ACC) and dorsolateral prefrontal cortex (DLPFC) in schizophrenia.
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Evidence for Abnormal Forward Trafficking of AMPA Receptors in Frontal Cortex of Elderly Patients with Schizophrenia
John C. Hammond,Robert E. McCullumsmith,Adam J. Funk,Vahram Haroutunian,James H. Meador-Woodruff +4 more
TL;DR: There is an alteration of forward trafficking of AMPA receptors as well as changes in the subcellular localization of an AMPA receptor subunit in schizophrenia, which is suggested to contribute to the pathophysiology of schizophrenia.
Journal ArticleDOI
Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia
Adam J. Funk,Gavin Rumbaugh,Vahram Harotunian,Robert E. McCullumsmith,James H. Meador-Woodruff +4 more
TL;DR: The data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia.
Journal ArticleDOI
Abnormalities of signal transduction networks in chronic schizophrenia
Jennifer L. McGuire,Erica A K DePasquale,Adam J. Funk,Sinead M. O’Donnovan,Kathryn Hasselfeld,Shruti Marwaha,John H. Hammond,Vahram Hartounian,Vahram Hartounian,James H. Meador-Woodruff,Jarek Meller,Jarek Meller,Robert E. McCullumsmith +12 more
TL;DR: The data indicate subtle changes in kinase activity and regulation across an interlinked kinase network, suggesting signaling imbalances underlie the core symptoms of schizophrenia.