Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia
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TLDR
Proteins and phospho-proteins comprising mitogen activated protein kinase (MAPK) and 3′–5′-cyclic adenosine monophosphate (cAMP)-associated signaling pathways may be abnormally expressed in the anterior cingulate (ACC) and dorsolateral prefrontal cortex (DLPFC) in schizophrenia.About:
This article is published in Neuropsychopharmacology.The article was published on 2012-03-01 and is currently open access. It has received 129 citations till now. The article focuses on the topics: Dorsolateral prefrontal cortex & Receptor expression.read more
Citations
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Journal ArticleDOI
Glutamate and dopamine in schizophrenia: an update for the 21st century
TL;DR: This review provides an update on the latest findings on dopamine and glutamate abnormalities in schizophrenia, focusing on in vivo neuroimaging studies in patients and clinical high-risk groups, and considers their implications for understanding the biology and treatment of schizophrenia.
Activation and signaling of the p38 MAP kinase pathway
TylerZARUBIN,JiahuaiHAN +1 more
TL;DR: The role of p38 as a signal transduction mediator is focused on and the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types is examined.
Journal ArticleDOI
Prefrontal Cortical Dendritic Spine Pathology in Schizophrenia and Bipolar Disorder
Glenn T. Konopaske,Glenn T. Konopaske,Nicholas Lange,Nicholas Lange,Joseph T. Coyle,Joseph T. Coyle,Francine M. Benes,Francine M. Benes +7 more
TL;DR: Dendritic spine loss in the DLPFC was seen in both individuals with schizophrenia and individuals with bipolar disorder, suggesting that the 2 disorders may share some common pathophysiological features.
Journal ArticleDOI
NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia
Melissa A. Snyder,Wen-Jun Gao +1 more
TL;DR: How disrupted NMDAR function leads to altered neurodevelopment that may contribute to the progression and development of symptoms for schizophrenia, particularly cognitive deficits is discussed.
Journal ArticleDOI
Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures.
TL;DR: Findings of moderate–large reductions in synaptophysin in hippocampus and frontal cortical regions, and a tendency for reductions in other pre- and postsynaptic proteins in the hippocampus are consistent with models that implicate synaptic loss in schizophrenia, but they also identify potential differences between regions and proteins, suggesting synaptic loss is not uniform in nature or extent.
References
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Signal integration by JNK and p38 MAPK pathways in cancer development
Erwin F. Wagner,Angel R. Nebreda +1 more
TL;DR: This Review highlights the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers.
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Pathological roles of MAPK signaling pathways in human diseases
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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
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Y. Tony Ip,Roger J. Davis +1 more
TL;DR: The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in mammals and insects as discussed by the authors, indicating that this signaling pathway may contribute to inflammatory responses.
Journal ArticleDOI
Activation and signaling of the p38 MAP kinase pathway
Tyler Zarubin,Jiahuai Han +1 more
TL;DR: The role of p38 as a signal transduction mediator is focused on and the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types is examined.
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