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Adam R. Wende
Researcher at University of Alabama at Birmingham
Publications - 101
Citations - 6488
Adam R. Wende is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Heart failure & Mitochondrion. The author has an hindex of 33, co-authored 85 publications receiving 5252 citations. Previous affiliations of Adam R. Wende include Sanford-Burnham Institute for Medical Research & University of Utah.
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Journal ArticleDOI
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
Keith Baar,Adam R. Wende,Terry E. Jones,Matthew Marison,Lorraine A. Nolte,May Chen,Daniel P. Kelly,John O. Holloszy +7 more
TL;DR: It is suggested that increases in PGC‐1, NRF‐ 1, andNRF‐2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that P GC‐1 mediates the coordinated increases in GLUT4 and mitochondria.
Journal ArticleDOI
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Teresa C. Leone,John J. Lehman,Brian N. Finck,Paul J. Schaeffer,Adam R. Wende,Sihem Boudina,Michael Courtois,David F. Wozniak,Nandakumar Sambandam,Carlos Bernal-Mizrachi,Zhouji Chen,John O. Holloszy,Denis M. Medeiros,Robert E. Schmidt,Jeffrey E. Saffitz,E. Dale Abel,Clay F. Semenkovich,Daniel P. Kelly +17 more
TL;DR: It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.
Journal ArticleDOI
PGC-1α Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERRα: a Mechanism for Transcriptional Control of Muscle Glucose Metabolism
TL;DR: It is found that physiological stimuli known to induce PGC-1α expression in skeletal muscle coordinately upregulate the expression of pyruvate dehydrogenase kinase 4 (PDK4), a negative regulator of glucose oxidation.
Journal ArticleDOI
Lipotoxicity in the heart
Adam R. Wende,E. Dale Abel +1 more
TL;DR: The state of knowledge regarding potential causes and correlates of increased myocardial lipid content in animal models and humans is reviewed and it is sought to highlight those areas where additional research is warranted.
Journal ArticleDOI
A Role for the Transcriptional Coactivator PGC-1α in Muscle Refueling *
Adam R. Wende,Paul J. Schaeffer,Glendon J. Parker,Christoph Peter Gerhard Zechner,Dong Ho Han,May M. Chen,Chad R. Hancock,John J. Lehman,Janice M. Huss,Donald A. McClain,John O. Holloszy,Daniel P. Kelly +11 more
TL;DR: Findings identify PGC-1α as a critical regulator of skeletal muscle fuel stores via several mechanisms including stimulation of glucose import, suppression of glycolytic flux, and by down-regulation of the expression of glycogen phosphorylase and its activating kinase, phosphoryLase kinase α.