K
Kimihiko Sano
Researcher at Kobe University
Publications - 79
Citations - 8716
Kimihiko Sano is an academic researcher from Kobe University. The author has contributed to research in topics: Protein kinase C & Gene expression. The author has an hindex of 33, co-authored 78 publications receiving 8610 citations. Previous affiliations of Kimihiko Sano include National Institutes of Natural Sciences, Japan & National Institute for Basic Biology, Japan.
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
TL;DR: Kinetic analysis indicates that TPA can substitute for diacylglycerol and greatly increases the affinity of the enzyme for Ca2+ as well as for phospholipid, and various phorbol derivatives which have been shown to be active in tumor promotion are also capable of activating this protein kinase in in vitro systems.
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A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.
TL;DR: The results indicate that thrombin and collagen activate platelets in almost similar mechanisms and that protein kinase C may lie on a common pathway which leads to the release of serotonin.
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Synergistic functions of phorbol ester and calcium in serotonin release from human platelets
Junji Yamanishi,Junji Yamanishi,Yoshimi Takai,Yoshimi Takai,Kozo Kaibuchi,Kozo Kaibuchi,Kimihiko Sano,Kimihiko Sano,Monique Castagna,Monique Castagna,Yasutomi Nishizuka,Yasutomi Nishizuka +11 more
TL;DR: A series of experiments with TPA and Ca2+-ionophore indicates that activation of protein kinase C is a prerequisite requirement for release of serotonin, and that this enzyme activation and Ca 2+ mobilization act synergistically to elicit a full cellular response.
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Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombin.
TL;DR: Human platelets contain a large amount of Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C), and phosphatidylinositol turnover provoked by thrombin seems to serve as a transmembrane signal for protein phosphorylation during platelet activation.
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PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.
Frank Rutsch,Sucheta M. Vaingankar,Kristen Johnson,Ira D. Goldfine,Betty A. Maddux,Petra Schauerte,Hermann Kalhoff,Kimihiko Sano,William A. Boisvert,Andrea Superti-Furga,Robert Terkeltaub +10 more
TL;DR: In this paper, a 25-month-old boy with idiopathic infantile arterial calcification (IIAC) and peri-articular calcification was assessed.