A
Adrian Ma
Researcher at Stanford University
Publications - 11
Citations - 2060
Adrian Ma is an academic researcher from Stanford University. The author has contributed to research in topics: Blood pressure & Denervation. The author has an hindex of 8, co-authored 10 publications receiving 1564 citations.
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Journal ArticleDOI
Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial
Raymond R. Townsend,Felix Mahfoud,Felix Mahfoud,David E. Kandzari,Kazuomi Kario,Stuart J. Pocock,Michael A. Weber,Sebastian Ewen,Konstantinos Tsioufis,Dimitrios Tousoulis,Andrew S.P. Sharp,A. Watkinson,Roland E. Schmieder,Axel Schmid,James W. Choi,Cara East,Anthony Walton,Ingrid Hopper,Debbie L. Cohen,Robert L. Wilensky,David P. Lee,Adrian Ma,Chandan Devireddy,Janice P. Lea,Philipp Lurz,Karl Fengler,Justin E. Davies,Neil Chapman,Sidney Cohen,Vanessa DeBruin,Martin Fahy,Denise E Jones,Martin T. Rothman,Michael Böhm,Jiro Aoki,Bryan Batson,George Dangas,Shukri David,David E. Kandzari,Manesh R. Patel,Kiritkumar Patel,Jasvindar Singh,Thomas Weber,Joachim Weil,Thomas Zeller,Khaled M. Ziada,Kengo Tanabe,Robert Wilkins,Johanna Contreras,Susan Steigerwalt,Denise Reedus,Satoshi Hoshide,Laura P. Svetkey,Anjani Rao,Angela L. Brown,Markus Suppan,Tolga Agdirlioglu,Elias Noory,Craig Chasen +58 more
TL;DR: Results from SPYRAL HTN-OFF MED provide biological proof of principle for the blood-pressure-lowering efficacy of renal denervation in the absence of antihypertensive medications.
Journal ArticleDOI
Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial
David E. Kandzari,Michael Böhm,Felix Mahfoud,Felix Mahfoud,Raymond R. Townsend,Michael A. Weber,Stuart J. Pocock,Konstantinos Tsioufis,Dimitrios Tousoulis,James W. Choi,Cara East,Sandeep Brar,Sidney Cohen,Martin Fahy,Garrett Pilcher,Kazuomi Kario,Jiro Aoki,Bryan Batson,Debbie L. Cohen,George Dangas,Shukri David,Justin E. Davies,Chandan Devireddy,David E. Kandzari,David P. Lee,Philipp Lurz,Vasilios Papademetriou,Manesh R. Patel,Kiritkumar Patel,Roland E. Schmieder,Andrew S.P. Sharp,Jasvindar Singh,Antony Walton,Thomas Weber,Joachim Weil,Thomas Zeller,Khaled M. Ziada,Kengo Tanabe,Robert Wilkins,Robert L. Wilensky,Johanna Contreras,Susan Steigerwalt,Neil Chapman,Janice P. Lea,Denise Reedus,Satoshi Hoshide,Adrian Ma,Karl Fengler,Ping Li,Laura P. Svetkey,Anjani Rao,Axel Schmid,A. Watkinson,Angela L. Brown,Ingrid Hopper,Markus Suppan,Tolga Agdirlioglu,Elias Noory,Craig Chasen +58 more
TL;DR: Renal denervation in the main renal arteries and branches significantly reduced blood pressure compared with sham control with no major safety events.
Journal ArticleDOI
Predictors of blood pressure response in the SYMPLICITY HTN-3 trial.
David E. Kandzari,Deepak L. Bhatt,Sandeep Brar,Chandan Devireddy,Murray D. Esler,Martin Fahy,John M. Flack,Barry T. Katzen,Janice P. Lea,David P. Lee,Martin B. Leon,Adrian Ma,Joseph M. Massaro,Laura Mauri,Suzanne Oparil,William W. O'Neill,Manesh R. Patel,Krishna J. Rocha-Singh,Paul A. Sobotka,Laura P. Svetkey,Raymond R. Townsend,George L. Bakris +21 more
TL;DR: Post hoc analyses reveal several potential confounding factors that may partially explain the unexpected blood pressure responses in both the sham control and RDN groups.
Journal ArticleDOI
Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial
Michael Böhm,Kazuomi Kario,David E. Kandzari,Felix Mahfoud,Felix Mahfoud,Michael A. Weber,Roland E. Schmieder,Konstantinos Tsioufis,Stuart J. Pocock,Dimitris Konstantinidis,James W. Choi,Cara East,David P. Lee,Adrian Ma,Sebastian Ewen,Debbie L. Cohen,Robert L. Wilensky,Chandan Devireddy,Janice P. Lea,Axel Schmid,Joachim Weil,Tolga Agdirlioglu,Denise Reedus,Brian K. Jefferson,David Reyes,Richard D'Souza,Andrew S.P. Sharp,Andrew S.P. Sharp,Faisal Sharif,Martin Fahy,Vanessa DeBruin,Sidney Cohen,Sandeep Brar,Raymond R. Townsend,Ertan Akarca,Suhail Allaqaband,Eirini Andrikou,Jiro Aoki,Ahran D. Arnold,Herbert D. Aronow,Masahiko Asami,William Bachinsky,John H. Barton,Kyle Bass,Bryan Batson,Christopher Bell,Barry Bertolet,Yvonne Bewarder,Karl Bihlmaier,Christian Binner,Jason Bloom,Benjamin Blossom,Somjot S Brar,Angela L. Brown,Robert E. Burke,Martin N. Burke,Michael Butler,William J. Calhoun,James Campbell,Steve Carroll,Neil Chapman,Craig Chasen,Shi Chi Cheng,Beth Chia,Nishit Choksi,Jordana B. Cohen,Niall Connolly,Johanna Contreras,Ronan Cusack,George Dangas,Shukri David,Justin E. Davies,Juliane Dederer,Matthew G. Denker,Udo Desch,Matthaios Didangelos,Thomas Dienemann,Kyriakos Dimitriadis,Jean François Dorval,John Estess,Sarah Fan,Karl Fengler,Lee Ferguson,Marat Fudim,Valentin Fuster,Fidel Garcia,Santiago Garcia,Alex Garton,Carl Gessler,Magdi Ghali,Bharat Gummadi,Amit Gupta,A.M. Gutiérrez,Peggy Hardesty,Phillip Hartung,Walter H. Haught,Yonghong Haun,Sara Hays,Wolfgang Helmreich,Douglas Hill,Ingrid Hopper,Yu Horiuchi,Satoshi Hoshide,James P. Howard,Wanda Ikeda,Fued Jan,Rajiv Jauhar,Desmond Jay,James R. Johnson,Thomas Johnston,Schuyler Jones,Susanne Jung,Theodoros Kalos,Mihar Kanitkar,Dennis Kannenkeril,Alexandros Kasiakogias,Samer Kazziha,Daniel Keene,Jayant Khitha,Hosei Kikushima,Taisei Kobayashi,Kota Komiyama,Takahiro Komori,John Kotter,Antonios Kouparanis,Joshua Krasnow,Saarraangan Kulenthiran,Sarwan Kumar,Philippe L. L’Allier,Phillip Laney,Lucas Lauder,Marc A. Lavoie,Matthias Lerche,Elena Linesky,Nelson Little,Carl Lomboy,Jelena Lucic,Philipp Lurz,Shannon Lynch,Prakash Mansukhani,Katie McDuffie,Brian McGrath,Brent T. McLaurin,Ashley Meade,Perwaiz Meraj,Dominic Millenaar,Naing Moore,Fumiko Mori,Phillip Munch,James R. Murphy,Jennifer M. Murray,Aravinda Nanjundappa,Kai Ninomiya,Yusuke Oba,Tim O'Connor,Yukiyo Ogata,Yukako Ogoyama,Rachel Onsrud,Christian Ott,Bimal Padaliya,Neha J. Pagidipati,Manesh R. Patel,Kiritkumar Patel,Emanouela Petteinidou,Wendy Porr,Anjani Rao,Rabia Razi,Christopher Regan,Michael Remetz,David Rizik,Monique Robison,Karl Philipp Rommel,Liesbeth Rosseel,Marcos Rothstein,Randolph Rough,Jose M. Saavedra,Souhell Saba,Robert S. Schwartz,Shaun Selcer,Sayan Sen,Jacqueline Sennott,Ramin Shadman,Samit Shah,Douglas Shemin,Hayato Shimizu,Masahisa Shimpo,Mehdi H. Shishehbor,Matthew J. Shun-Shin,Francisco Sierra,Jasvindar Singh,Avneet Singh,Yassir Sirajeldin,Nedaa Skeik,George Soliman,Sarah Statton,Julia Stehli,Susan Steigerwalt,Kristina Striepe,Jason Stuck,Markus Suppan,Laura P. Svetkey,Ganpat Takker,Kengo Tanabe,Tetsu Tanaka,Daijiro Tomii,Sabino Torre,Jay H. Traverse,Crystal C. Tyson,Alejandro Arias Vasquez,Enrique Velasquez,Sreekanth Vemulapalli,Hirotaka Waki,Tony Walton,Yale Wang,Thomas Weber,Bryan Wells,Robert Wilkins,Thomas C. Wright,Kazuyuki Yahagi,Alan C. Yeung,Ray Zadegan,Thomas Zeller,Khaled M. Ziada,Antonios Ziakas,David A. Zidar +224 more
TL;DR: The SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial showed the superiority of catheter-based renal denervation compared with a sham procedure to safely lower blood pressure in the absence of antihypertensive medications.
Journal ArticleDOI
Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans.
Andreas Wolf,Christoff Zalpour,Gregor Theilmeier,Bing Yin Wang,Adrian Ma,Barbara Anderson,Philip S. Tsao,John P. Cooke +7 more
TL;DR: This double-blinded, placebo-controlled study demonstrates that dietary supplementation with L-arginine can modestly attenuate the increased platelet reactivity seen in hypercholesterolemic patients and restores endogenous nitric oxide activity and inhibits platelet aggregation.