V
Vanessa DeBruin
Publications - 9
Citations - 850
Vanessa DeBruin is an academic researcher. The author has contributed to research in topics: Medicine & Blood pressure. The author has an hindex of 2, co-authored 2 publications receiving 564 citations.
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Journal ArticleDOI
Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial
Raymond R. Townsend,Felix Mahfoud,Felix Mahfoud,David E. Kandzari,Kazuomi Kario,Stuart J. Pocock,Michael A. Weber,Sebastian Ewen,Konstantinos Tsioufis,Dimitrios Tousoulis,Andrew S.P. Sharp,A. Watkinson,Roland E. Schmieder,Axel Schmid,James W. Choi,Cara East,Anthony Walton,Ingrid Hopper,Debbie L. Cohen,Robert L. Wilensky,David P. Lee,Adrian Ma,Chandan Devireddy,Janice P. Lea,Philipp Lurz,Karl Fengler,Justin E. Davies,Neil Chapman,Sidney Cohen,Vanessa DeBruin,Martin Fahy,Denise E Jones,Martin T. Rothman,Michael Böhm,Jiro Aoki,Bryan Batson,George Dangas,Shukri David,David E. Kandzari,Manesh R. Patel,Kiritkumar Patel,Jasvindar Singh,Thomas Weber,Joachim Weil,Thomas Zeller,Khaled M. Ziada,Kengo Tanabe,Robert Wilkins,Johanna Contreras,Susan Steigerwalt,Denise Reedus,Satoshi Hoshide,Laura P. Svetkey,Anjani Rao,Angela L. Brown,Markus Suppan,Tolga Agdirlioglu,Elias Noory,Craig Chasen +58 more
TL;DR: Results from SPYRAL HTN-OFF MED provide biological proof of principle for the blood-pressure-lowering efficacy of renal denervation in the absence of antihypertensive medications.
Journal ArticleDOI
Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial
Michael Böhm,Kazuomi Kario,David E. Kandzari,Felix Mahfoud,Felix Mahfoud,Michael A. Weber,Roland E. Schmieder,Konstantinos Tsioufis,Stuart J. Pocock,Dimitris Konstantinidis,James W. Choi,Cara East,David P. Lee,Adrian Ma,Sebastian Ewen,Debbie L. Cohen,Robert L. Wilensky,Chandan Devireddy,Janice P. Lea,Axel Schmid,Joachim Weil,Tolga Agdirlioglu,Denise Reedus,Brian K. Jefferson,David Reyes,Richard D'Souza,Andrew S.P. Sharp,Andrew S.P. Sharp,Faisal Sharif,Martin Fahy,Vanessa DeBruin,Sidney Cohen,Sandeep Brar,Raymond R. Townsend,Ertan Akarca,Suhail Allaqaband,Eirini Andrikou,Jiro Aoki,Ahran D. Arnold,Herbert D. Aronow,Masahiko Asami,William Bachinsky,John H. Barton,Kyle Bass,Bryan Batson,Christopher Bell,Barry Bertolet,Yvonne Bewarder,Karl Bihlmaier,Christian Binner,Jason Bloom,Benjamin Blossom,Somjot S Brar,Angela L. Brown,Robert E. Burke,Martin N. Burke,Michael Butler,William J. Calhoun,James Campbell,Steve Carroll,Neil Chapman,Craig Chasen,Shi Chi Cheng,Beth Chia,Nishit Choksi,Jordana B. Cohen,Niall Connolly,Johanna Contreras,Ronan Cusack,George Dangas,Shukri David,Justin E. Davies,Juliane Dederer,Matthew G. Denker,Udo Desch,Matthaios Didangelos,Thomas Dienemann,Kyriakos Dimitriadis,Jean François Dorval,John Estess,Sarah Fan,Karl Fengler,Lee Ferguson,Marat Fudim,Valentin Fuster,Fidel Garcia,Santiago Garcia,Alex Garton,Carl Gessler,Magdi Ghali,Bharat Gummadi,Amit Gupta,A.M. Gutiérrez,Peggy Hardesty,Phillip Hartung,Walter H. Haught,Yonghong Haun,Sara Hays,Wolfgang Helmreich,Douglas Hill,Ingrid Hopper,Yu Horiuchi,Satoshi Hoshide,James P. Howard,Wanda Ikeda,Fued Jan,Rajiv Jauhar,Desmond Jay,James R. Johnson,Thomas Johnston,Schuyler Jones,Susanne Jung,Theodoros Kalos,Mihar Kanitkar,Dennis Kannenkeril,Alexandros Kasiakogias,Samer Kazziha,Daniel Keene,Jayant Khitha,Hosei Kikushima,Taisei Kobayashi,Kota Komiyama,Takahiro Komori,John Kotter,Antonios Kouparanis,Joshua Krasnow,Saarraangan Kulenthiran,Sarwan Kumar,Philippe L. L’Allier,Phillip Laney,Lucas Lauder,Marc A. Lavoie,Matthias Lerche,Elena Linesky,Nelson Little,Carl Lomboy,Jelena Lucic,Philipp Lurz,Shannon Lynch,Prakash Mansukhani,Katie McDuffie,Brian McGrath,Brent T. McLaurin,Ashley Meade,Perwaiz Meraj,Dominic Millenaar,Naing Moore,Fumiko Mori,Phillip Munch,James R. Murphy,Jennifer M. Murray,Aravinda Nanjundappa,Kai Ninomiya,Yusuke Oba,Tim O'Connor,Yukiyo Ogata,Yukako Ogoyama,Rachel Onsrud,Christian Ott,Bimal Padaliya,Neha J. Pagidipati,Manesh R. Patel,Kiritkumar Patel,Emanouela Petteinidou,Wendy Porr,Anjani Rao,Rabia Razi,Christopher Regan,Michael Remetz,David Rizik,Monique Robison,Karl Philipp Rommel,Liesbeth Rosseel,Marcos Rothstein,Randolph Rough,Jose M. Saavedra,Souhell Saba,Robert S. Schwartz,Shaun Selcer,Sayan Sen,Jacqueline Sennott,Ramin Shadman,Samit Shah,Douglas Shemin,Hayato Shimizu,Masahisa Shimpo,Mehdi H. Shishehbor,Matthew J. Shun-Shin,Francisco Sierra,Jasvindar Singh,Avneet Singh,Yassir Sirajeldin,Nedaa Skeik,George Soliman,Sarah Statton,Julia Stehli,Susan Steigerwalt,Kristina Striepe,Jason Stuck,Markus Suppan,Laura P. Svetkey,Ganpat Takker,Kengo Tanabe,Tetsu Tanaka,Daijiro Tomii,Sabino Torre,Jay H. Traverse,Crystal C. Tyson,Alejandro Arias Vasquez,Enrique Velasquez,Sreekanth Vemulapalli,Hirotaka Waki,Tony Walton,Yale Wang,Thomas Weber,Bryan Wells,Robert Wilkins,Thomas C. Wright,Kazuyuki Yahagi,Alan C. Yeung,Ray Zadegan,Thomas Zeller,Khaled M. Ziada,Antonios Ziakas,David A. Zidar +224 more
TL;DR: The SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial showed the superiority of catheter-based renal denervation compared with a sham procedure to safely lower blood pressure in the absence of antihypertensive medications.
Journal ArticleDOI
Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial
Deepak L. Bhatt,Muthiah Vaduganathan,David E. Kandzari,Martin B. Leon,Krishna J. Rocha-Singh,Raymond R. Townsend,Barry T. Katzen,Suzanne Oparil,Sandeep S. Brar,Vanessa DeBruin,Martin Fahy,George L. Bakris,Sidney Cohen,Ralph A D'Agostino,Murray D. Esler,John M. Flack,B.B. Katzen,Laura Mauri,Manuela Negoita,Ziad A. Abbud,Tayo Addo,David E. Anderson,John S. Angle,Herbert D. Aronow,Anvar Babaev,Keith H. Benzuly,Somjot S Brar,David Brown,D Calhoun,P A Casale,Sheldon Chaffer,James W. Choi,Eugene Chung,Debbie L. Cohen,Mark A. Creager,George Dangas,Harold L. Dauerman,Shukri David,Mark Davies,Eduardo de Marchena,Ali E. Denktas,Chandan Devireddy,William E. Downey,Mark E. Dunlap,D. Charles Fisher,Magdi Ghali,Eric Gnall,Raghava R. Gollapudi,Mark Goodwin,Nilesh J. Goswami,Luis Gruberg,Rajiv Gulati,Anuj Gupta,Anjan Gupta,Hitinder S. Gurm,Jeffrey W. Hastings,Scott Kinlay,Robert Kipperman,Maurice Buchbinder,Ajay J. Kirtane,Richard Kovach,David P. Lee,Samuel G. Mann,Steven P. Marso,Fadi Youssef Matar,E. M. Mazzaferri,Farrel Mandelsohn,Issam Moussa,Timothy N Murphy,Sandeep Nathan,Brian H. Negus,Sahil A. Parikh,Manesh R. Patel,Kirikumar Patel,Basil M. Paulus,George Petrossian,Alex Fritz Powell,Jacek J. Preibisz,Florian Rader,Otelio S. Randall,Mahmood K. Razavi,J. Reilly,Jonathan S. Reiner,Michael Ring,Mark Robbins,Kevin L. Rogers,N. Ruggiero,Renato M. Santos,William Wyatt Little,John Schindler,T. Scott,Thomas M. Shimshak,Mehdi H. Shishehbor,Mitchell Silver,Jasvindar Singh,K. Singh,David P. Slovut,Rick G Stoufer,Paul Teirsten,Thomas M. Todoran,George W. Vetrovec,Ron Waksman,Yale Wang,Sergio Waxman,R. C. Wilkins,Khaled M. Ziada,Frank J. Zidar +106 more
TL;DR: The SYMPLICITY HTN-3 trial showed the safety but not efficacy of the Symplicity system at 6 months follow-up in patients with treatment-resistant hypertension, and long-term blood pressure changes in renal artery denervation and sham control groups are reported.
Journal ArticleDOI
Twenty-Four-Hour Pulsatile Hemodynamics Predict Brachial Blood Pressure Response to Renal Denervation in the SPYRAL HTN-OFF MED Trial
Thomas Weber,Siegfried Wassertheurer,Christopher C. Mayer,Bernhard Hametner,Kathrin Danninger,Raymond R. Townsend,Felix Mahfoud,Kazuomi Kario,Martin Fahy,Vanessa DeBruin,Nicole Peterson,Manuela Negoita,Michael A. Weber,David E. Kandzari,Roland E. Schmieder,Constantinos Tsioufis,Ronald K. Binder,Michael Böhm +17 more
TL;DR: It is suggested that pulsatile hemodynamics, obtained during 24-hour ambulatory BP monitoring, may predict BP response to RDN.
Journal ArticleDOI
Patient preferences for pharmaceutical and interventional hypertension treatments: results from a discrete choice experiment
Atul Arun Pathak,Michael A. Weber,Christine Poulos,Joshua R. Coulter,Sidney Cohen,Vanessa DeBruin,Denise Jones,David E. Kandzari +7 more
TL;DR: Among U.S. patients with HTN, a DCE study demonstrated thatBP reduction was the most important driver of choice, risks were less important, and a minimal BP reduction was sufficient to offset treatment risks associated with an interventional procedure like RDN.