A
Aedín C. Culhane
Researcher at Harvard University
Publications - 98
Citations - 11493
Aedín C. Culhane is an academic researcher from Harvard University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 42, co-authored 92 publications receiving 8954 citations. Previous affiliations of Aedín C. Culhane include City University of New York & University College Dublin.
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Journal ArticleDOI
Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification
Myles Smith,Aedín C. Culhane,Maryanne Donovan,John Calvin Coffey,B. D. Barry,M A Kelly,Desmond G. Higgins,Jeffrey Tze-Yee Wang,W. O. Kirwan,Thomas G. Cotter,Henry Paul Redmond +10 more
TL;DR: FACS was found to be a robust method for generating samples for gene expression analysis, allowing simultaneous assessment of parenchymal and stromal compartments and gross stromAL contamination may affect the interpretation of cancer gene expression microarray experiments.
Journal ArticleDOI
MOGSA: Integrative Single Sample Gene-set Analysis of Multiple Omics Data.
Chen Meng,Azfar Basunia,Bjoern Peters,Amin Moghaddas Gholami,Bernhard Kuster,Aedín C. Culhane +5 more
TL;DR: A new computation method termed multi-omics gene-set analysis (MOGSA), a multivariate single sample gene- set analysis method that integrates multiple experimental and molecular data types measured over the same set of samples is introduced.
Journal ArticleDOI
Significance Analysis of Prognostic Signatures
Andrew H. Beck,Nicholas W. Knoblauch,Marco M. Hefti,Jennifer Kaplan,Stuart J. Schnitt,Aedín C. Culhane,Markus S. Schroeder,Thomas Risch,John Quackenbush,Benjamin Haibe-Kains +9 more
TL;DR: Significance Analysis of Prognostic Signatures (SAPS) is a powerful new method for deriving robust prognostic biological signatures from clinically annotated genomic datasets and is used to perform a large meta-analysis of prognostic pathways in breast and ovarian cancer and their molecular subtypes.
Journal ArticleDOI
Integrating transcription factor binding site information with gene expression datasets
Ian B. Jeffery,Stephen F. Madden,Paul A. McGettigan,Guy Perrière,Aedín C. Culhane,Desmond G. Higgins +5 more
TL;DR: This work combines correspondence analysis, between group analysis and co-inertia analysis, to determine which motifs are strongly associated with differences in gene expression levels from a database of promoter motifs.
Posted ContentDOI
Deep phenotyping of 34,128 patients hospitalised with COVID-19 and a comparison with 81,596 influenza patients in America, Europe and Asia: an international network study
Edward Burn,Seng Chan You,Anthony G. Sena,Anthony G. Sena,Kristin Kostka,Hamed Abedtash,Maria Tereza Fernandes Abrahão,Amanda Alberga,Heba Alghoul,Osaid Alser,Thamir M. Alshammari,M Aragon,Carlos Areia,Juan M. Banda,Jaehyeong Cho,Aedín C. Culhane,Alexander Davydov,Frank J. DeFalco,Talita Duarte-Salles,Scott L. DuVall,Scott L. DuVall,Thomas Falconer,Sergio Fernandez-Bertolin,Weihua Gao,Asieh Golozar,Jill Hardin,George Hripcsak,Vojtech Huser,Hokyun Jeon,Yonghua Jing,Chi Young Jung,Benjamin Skov Kaas-Hansen,Denys Kaduk,Seamus Kent,Yeesuk Kim,Spyros Kolovos,Jennifer C E Lane,Hyejin Lee,Kristine E. Lynch,Kristine E. Lynch,Rupa Makadia,Michael E. Matheny,Paras P. Mehta,Daniel R. Morales,Karthik Natarajan,Fredrik Nyberg,Anna Ostropolets,Rae Woong Park,Jimyung Park,Jose D. Posada,Albert Prats-Uribe,Gowtham A. Rao,Christian G. Reich,Yeunsook Rho,Peter R. Rijnbeek,Lisa M. Schilling,Martijn J. Schuemie,Martijn J. Schuemie,Nigam H. Shah,Azza Shoaibi,Seok Young Song,Matthew E. Spotnitz,Marc A. Suchard,Joel N. Swerdel,David Vizcaya,Salvatore Volpe,Haini Wen,Andrew E. Williams,Belay Birlie Yimer,Lin Zhang,Lin Zhang,Oleg Zhuk,Daniel Prieto-Alhambra,Patrick B. Ryan,Patrick B. Ryan +74 more
TL;DR: Rates of comorbidities and medication use are high among individuals hospitalised with CO VID-19, however, COVID-19 patients are more likely to be male and appear to be younger and, in the US, generally healthier than those typically admitted with influenza.