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Aimee W. Kao
Researcher at University of California, San Francisco
Publications - 51
Citations - 2754
Aimee W. Kao is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Neurodegeneration & Frontotemporal lobar degeneration. The author has an hindex of 23, co-authored 45 publications receiving 2205 citations. Previous affiliations of Aimee W. Kao include University of Iowa.
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Journal ArticleDOI
Inhibition of Clathrin-Mediated Endocytosis Selectively Attenuates Specific Insulin Receptor Signal Transduction Pathways
TL;DR: The data demonstrate that the acute actions of insulin are largely independent of insulin receptor endocytosis and are initiated by activation of the plasma membrane-localized insulin receptor.
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Dynamin Is Required for Recombinant Adeno-Associated Virus Type 2 Infection
TL;DR: It is demonstrated that rAAV-2 infection is partially dependent on dynamin function, a GTPase protein involved in clathrin-mediated internalization of receptors and their ligands from the plasma membrane.
Journal ArticleDOI
The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism
Scott A. Summers,Aimee W. Kao,Aimee D. Kohn,Gillian S. Backus,Richard A. Roth,Jeffrey E. Pessin,Morris J. Birnbaum +6 more
TL;DR: The hypothesis that GSK3β contributes to insulin regulation of glycogen synthesis, but is not responsible for the increase in glucose transport is supported.
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Clinicopathological correlations in behavioural variant frontotemporal dementia.
David C. Perry,Jesse A. Brown,Katherine L. Possin,Samir Datta,Andrew Trujillo,Anneliese Radke,Anneliese Radke,Anna Karydas,John Kornak,Ana C. Sias,Gil D. Rabinovici,Maria Luisa Gorno-Tempini,Adam L. Boxer,Mary De May,Katherine P. Rankin,Virginia E. Sturm,Suzee E. Lee,Brandy R. Matthews,Brandy R. Matthews,Aimee W. Kao,Keith A. Vossel,Keith A. Vossel,Maria Carmela Tartaglia,Maria Carmela Tartaglia,Zachary A. Miller,Sang Won Seo,Sang Won Seo,Manu Sidhu,Stephanie E. Gaus,Alissa L. Nana,Jose Norberto S. Vargas,Ji Hye L. Hwang,Rik Ossenkoppele,Rik Ossenkoppele,Alainna B. Brown,Alainna B. Brown,Eric J. Huang,Giovanni Coppola,Howard J. Rosen,Daniel H. Geschwind,John Q. Trojanowski,Lea T. Grinberg,Joel H. Kramer,Bruce L. Miller,William W. Seeley +44 more
TL;DR: In this paper, the authors explored clinicopathological correlations in a large bvFTD cohort and used a combination of known predictive factors (genetic mutations, motor features, or striking atrophy patterns) and the results of a discriminant function analysis that incorporated clinical, neuroimaging and neuropsychological data.
Journal ArticleDOI
Progranulin, lysosomal regulation and neurodegenerative disease
TL;DR: Recent advances in progranulin biology are reviewed, emphasizing its roles in lysosomal function and brain innate immunity, and future avenues of investigation that may lead to new therapeutic approaches for neurodegeneration are outlined.