Aitziber Ugalde-Olano

TL;DR: A signature based on the PGC1α–ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment.

TL;DR: It is shown that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity.

TL;DR: E elevated levels of the steroid hormone, 3beta-hydroxyandros-5-en-17-one-3-sulphate (dehydroepiandrosterone sulphate) in PCa urinary EVs is found, in line with the potential elevation of androgen synthesis in this type of cancer.

TL;DR: It is shown that urinary EV from prostate cancer patients exhibit genuine and differential physical and biological properties compared to benign prostate hyperplasia (BPH) and transcriptomics characterization of uEVs led to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients.

TL;DR: The results support the feasibility of analyzing exosomes-associated miRNAs using a methodology that requires a small volume of urine and is compatible with a clinical environment and high-throughput analysis.