Patricia Zúñiga-García

TL;DR: A signature based on the PGC1α–ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment.

TL;DR: It is shown that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity.

TL;DR: The results show that the isolation of uEVs is feasible from small volumes of urine and avoiding ultracentrifugation, making easier the analysis in a clinical facility, but caution should be taken in the selection of the enrichment method since they have a differential affinity for protein u EVs markers and by extension for different subpopulation of EVs.

TL;DR: E elevated levels of the steroid hormone, 3beta-hydroxyandros-5-en-17-one-3-sulphate (dehydroepiandrosterone sulphate) in PCa urinary EVs is found, in line with the potential elevation of androgen synthesis in this type of cancer.

TL;DR: The notion that loss of TRIB3 is associated with a more aggressive phenotype in various types of tumors by enhancing the activity of the mTORC2/AKT/FOXO axis is supported.