Giampaolo Morciano

TL;DR: The different molecular players involved in the transfer of Ca2+ ions from the ER lumen to the mitochondrial matrix are described and how modifications in both ER-mitochondria contact sites andCa2+ signaling can alter the cell death execution program are described.

TL;DR: The molecular factors involved in the regulation and formation of the mitochondrial permeability transition pore are reviewed and it is proposed that the mitochondrial ATP synthase, specifically its c subunit, is the central core component of the mPTP complex.

TL;DR: A signature based on the PGC1α–ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment.

TL;DR: An update regarding the key roles of ROS-mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging is provided, highlighting that mitochondrial ROS may be a decisive target in clinical practice.

TL;DR: Molecular pathways in which melatonin is considered a master regulator, with attention to cell death and inflammation mechanisms from basic, translational and clinical points of view in the context of newborn care are summarized.