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Ana Loizaga-Iriarte
Researcher at University of the Basque Country
Publications - 19
Citations - 614
Ana Loizaga-Iriarte is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 9, co-authored 18 publications receiving 453 citations.
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Journal ArticleDOI
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.
Verónica Torrano,Lorea Valcarcel-Jimenez,Ana R. Cortazar,Xiaojing Liu,Jelena Urosevic,Mireia Castillo-Martin,Mireia Castillo-Martin,Sonia Fernández-Ruiz,Giampaolo Morciano,Alfredo Caro-Maldonado,Marc Guiu,Patricia Zúñiga-García,Mariona Graupera,Anna Bellmunt,Pahini Pandya,Mar Lorente,Natalia Martín-Martín,James D. Sutherland,Pilar Sanchez-Mosquera,Laura Bozal-Basterra,Amaia Zabala-Letona,Amaia Arruabarrena-Aristorena,Antonio Berenguer,Nieves Embade,Aitziber Ugalde-Olano,Isabel Lacasa-Viscasillas,Ana Loizaga-Iriarte,M. Unda-Urzaiz,Nikolaus Schultz,Ana M. Aransay,Victoria Sanz-Moreno,Rosa Barrio,Guillermo Velasco,Paolo Pinton,Carlos Cordon-Cardo,Jason W. Locasale,Roger R. Gomis,Arkaitz Carracedo,Arkaitz Carracedo +38 more
TL;DR: A signature based on the PGC1α–ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment.
Journal ArticleDOI
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Amaia Zabala-Letona,Amaia Arruabarrena-Aristorena,Natalia Martín-Martín,Sonia Fernández-Ruiz,James D. Sutherland,Michelle Clasquin,Julen Tomás-Cortázar,Jose Jimenez,Inés Cristina Torres,Phong Quang,Pilar Ximénez-Embún,Ruzica Bago,Aitziber Ugalde-Olano,Ana Loizaga-Iriarte,Isabel Lacasa-Viscasillas,Miguel Unda,Verónica Torrano,Diana Cabrera,Sebastiaan M. Van Liempd,Ylenia Cendon,Elena Castro,Stuart Murray,Ajinkya Revandkar,Andrea Alimonti,Yinan Zhang,Amelia Barnett,Gina Lein,David Pirman,Ana R. Cortazar,Leire Arreal,Ludmila Prudkin,Ianire Astobiza,Lorea Valcarcel-Jimenez,Patricia Zúñiga-García,Itziar Fernández-Domínguez,Marco Piva,Alfredo Caro-Maldonado,Pilar Sanchez-Mosquera,Mireia Castillo-Martin,Mireia Castillo-Martin,Violeta Serra,Violeta Serra,Naiara Beraza,Antonio Gentilella,George Thomas,Mikel Azkargorta,Felix Elortza,Rosa Farràs,David Olmos,Alejo Efeyan,Juan Anguita,Javier Muñoz,Juan M. Falcón-Pérez,Juan M. Falcón-Pérez,Rosa Barrio,Teresa Macarulla,Teresa Macarulla,José M. Mato,María L. Martínez-Chantar,Carlos Cordon-Cardo,Ana M. Aransay,Kevin R Marks,José Baselga,Josep Tabernero,Josep Tabernero,Paolo Nuciforo,Brendan D. Manning,Katya Marjon,Arkaitz Carracedo +68 more
TL;DR: It is shown that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity.
Journal ArticleDOI
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression.
Marc Clos-Garcia,Ana Loizaga-Iriarte,Patricia Zúñiga-García,Pilar Sanchez-Mosquera,Ana R. Cortazar,Esperanza Gonzalez,Verónica Torrano,Cristina Alonso,Miriam Pérez-Cormenzana,Aitziber Ugalde-Olano,Isabel Lacasa-Viscasillas,A. Castro,Felix Royo,Miguel Unda,Arkaitz Carracedo,Juan M. Falcón-Pérez +15 more
TL;DR: E elevated levels of the steroid hormone, 3beta-hydroxyandros-5-en-17-one-3-sulphate (dehydroepiandrosterone sulphate) in PCa urinary EVs is found, in line with the potential elevation of androgen synthesis in this type of cancer.
Journal ArticleDOI
Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer.
Verónica Torrano,Felix Royo,Héctor Peinado,Ana Loizaga-Iriarte,Miguel Unda,Juan M. Falcón-Pérez,Arkaitz Carracedo,Arkaitz Carracedo +7 more
TL;DR: This review provides an updated view of the potential of exosomes and microvesicles as biomarkers and the available technologies for their isolation.
Journal ArticleDOI
Comparative miRNA Analysis of Urine Extracellular Vesicles Isolated through Five Different Methods.
Felix Royo,Izzuddin Diwan,Michael R. Tackett,Patricia Zuñiga,Pilar Sanchez-Mosquera,Ana Loizaga-Iriarte,Aitziber Ugalde-Olano,Isabel Lacasa,Amparo Perez,Miguel Unda,Arkaitz Carracedo,Juan M. Falcón-Pérez +11 more
TL;DR: The results support the feasibility of analyzing exosomes-associated miRNAs using a methodology that requires a small volume of urine and is compatible with a clinical environment and high-throughput analysis.