Leire Arreal

TL;DR: It is shown that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity.

TL;DR: It is shown that PML is a novel target in aggressive breast cancer, and a novel pathway sustaining breast cancer aggressiveness that can be therapeutically exploited in combination with PML-based stratification is identified.

TL;DR: It is demonstrated that TNBC cells are addicted to the expression of the Promyelocytic Leukemia protein, and PML is associated to the promoter regions of MYC and PIM1, consistent with their direct correlation in breast cancer specimens.

TL;DR: Findings challenge the presumption that the function of the nuclear receptor PPARβ/δ in cancer is dictated by ligand-mediated activation and illuminate the oncosuppressive function of PPARD and understanding of the pathogenic molecular pathways elicited by this nuclear receptor.

TL;DR: Treatment with anti-cholesterolemic drugs, statins, at doses achieved in patients, enhance the pro-tumorigenic activity of obesogenic diets and reveal a prostate cancer experimental system where statins exhibit an undesirable effect.