Amaia Arruabarrena-Aristorena

TL;DR: A signature based on the PGC1α–ERRα pathway exhibited prognostic potential in prostate cancer, thus uncovering the relevance of monitoring and manipulating this pathway for prostate cancer stratification and treatment.

TL;DR: It is shown that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity.

TL;DR: It is shown that both the catalytic and non-catalytic APC/C-Fzr1/Cdh1-mediated activities of PTEN are required for stalk cells' proliferative arrest, and a Notch–PTEN signalling axis as an orchestrator of vessel density is defined.

TL;DR: This review enumerate and discuss current views of the regulation and activity of polyamine metabolism in tumor cell biology and describes polyamines as the oil that lubricates the cancer engine because they affect the activity of biological processes.

TL;DR: It is shown that urinary EV from prostate cancer patients exhibit genuine and differential physical and biological properties compared to benign prostate hyperplasia (BPH) and transcriptomics characterization of uEVs led to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients.