Akiko Noma

TL;DR: Analysis of kidney samples from patients with lupus nephritis and healthy control subjects revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses.

TL;DR: The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U), is required for the proper decoding of NNR codons in eukaryotes and the 2-thio group confers conformational rigidity of mcm5S2U by largely fixing the C3′-endo ribose puckering, ensuring stable and accurate codon–anticodon pairing.

TL;DR: To identify genes responsible for yW synthesis from uncharacterized genes of Saccharomyces cerevisiae, a systematic reverse genetic approach combined with mass spectrometry (‘ribonucleome analysis’) revealed its sequential biosynthetic pathway.

TL;DR: The cellular machinery underlying the exit of megaRNPs via budding is established, an explanation for the "nuclear blebbing" phenotype found in dystonia models is offered, and an important link between Torsin and the synaptic phenotypes observed in Dystonia is provided.

TL;DR: A systematic genomewide screening method that uses a reverse genetic approach combined with mass spectrometry, which is named "ribonucleome analysis," to identify uncharacterized genes that are involved in generating RNA modifications.