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Adam Chicoine
Researcher at Brigham and Women's Hospital
Publications - 10
Citations - 996
Adam Chicoine is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Lupus nephritis & Chemokine receptor. The author has an hindex of 7, co-authored 10 publications receiving 699 citations. Previous affiliations of Adam Chicoine include Ragon Institute of MGH, MIT and Harvard & Harvard University.
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Journal ArticleDOI
The immune cell landscape in kidneys of patients with lupus nephritis
Arnon Arazi,Deepak A. Rao,Celine C. Berthier,Anne Davidson,Yanyan Liu,Paul Hoover,Adam Chicoine,Thomas Eisenhaure,A. Helena Jonsson,Shuqiang Li,David J. Lieb,Fan Zhang,Kamil Slowikowski,Edward P. Browne,Akiko Noma,Danielle Sutherby,Scott Steelman,Dawn E. Smilek,Patti Tosta,William Apruzzese,Elena Massarotti,Maria Dall'Era,Meyeon Park,Diane L. Kamen,Richard A. Furie,Fernanda Payan-Schober,William F. Pendergraft,Elizabeth A. McInnis,Jill P. Buyon,Michelle Petri,Chaim Putterman,Kenneth C. Kalunian,E. Steve Woodle,James A. Lederer,David A. Hildeman,David A. Hildeman,Chad Nusbaum,Soumya Raychaudhuri,Matthias Kretzler,Jennifer H. Anolik,Michael B. Brenner,David Wofsy,Nir Hacohen,Betty Diamond +43 more
TL;DR: Analysis of kidney samples from patients with lupus nephritis and healthy control subjects revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses.
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Innate Response Activator B Cells Protect Against Microbial Sepsis
Philipp J. Rauch,Aleksey Chudnovskiy,Clinton S. Robbins,Georg F. Weber,Martin Etzrodt,Ingo Hilgendorf,Elizabeth Tiglao,Jose-Luiz Figueiredo,Yoshiko Iwamoto,Igor Theurl,Rostic Gorbatov,Michael T. Waring,Adam Chicoine,Majd Mouded,Mikael J. Pittet,Matthias Nahrendorf,Ralph Weissleder,Filip K. Swirski +17 more
TL;DR: An effector B cell population that protects against microbial sepsis is described that is phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor.
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Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue
Laura T. Donlin,Laura T. Donlin,Deepak A. Rao,Kevin Wei,Kamil Slowikowski,Kamil Slowikowski,Mandy J. McGeachy,Jason D. Turner,Nida Meednu,Fumitaka Mizoguchi,Maria Gutierrez-Arcelus,Maria Gutierrez-Arcelus,David J. Lieb,Joshua Keegan,Kaylin Muskat,Joshua Hillman,Cristina Rozo,Edd Ricker,Edd Ricker,Thomas Eisenhaure,Shuqiang Li,Edward P. Browne,Adam Chicoine,Danielle Sutherby,Akiko Noma,Accelerating Medicines Partnership Ra,Chad Nusbaum,Stephen Kelly,Stephen Kelly,Alessandra B. Pernis,Alessandra B. Pernis,Lionel B. Ivashkiv,Lionel B. Ivashkiv,Susan M. Goodman,William H. Robinson,Paul J. Utz,James A. Lederer,Ellen M. Gravallese,Brendan F. Boyce,Nir Hacohen,Costantino Pitzalis,Peter K. Gregersen,Gary S. Firestein,Soumya Raychaudhuri,Larry W. Moreland,V. Michael Holers,V. Michael Holers,Vivian P. Bykerk,Andrew Filer,David L. Boyle,Michael B. Brenner,Jennifer H. Anolik +51 more
TL;DR: A robust protocol to acquire viable cells from cryopreserved synovial tissue with intact transcriptomes and cell surface phenotypes is established and integrated analysis of large patient cohorts may help define molecular heterogeneity within RA pathology and identify new therapeutic targets and biomarkers.
Journal ArticleDOI
Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis
Gaurav D. Gaiha,Kevin J. McKim,Matthew Woods,Thomas Pertel,Janine Rohrbach,Natasha S. Barteneva,Christopher R. Chin,Christopher R. Chin,Dongfang Liu,Damien Z. Soghoian,Kevin Cesa,Shannon Wilton,Michael T. Waring,Michael T. Waring,Adam Chicoine,Travis A. Doering,E. John Wherry,Daniel Kaufmann,Daniel Kaufmann,Mathias Lichterfeld,Mathias Lichterfeld,Abraham L. Brass,Abraham L. Brass,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker +25 more
TL;DR: Chronic stimulation leading to upregulated caspase-8 activity contributes to dysfunctional HIV-specific CD8(+) T cell proliferation through activation of necroptosis and increased cell death.
Journal ArticleDOI
Ets-1 Maintains IL-7 Receptor Expression in Peripheral T Cells
Roland Grenningloh,Roland Grenningloh,Tzong-Shyuan Tai,Nicole Frahm,Nicole Frahm,Tomoyuki C. Hongo,Adam Chicoine,Christian Brander,Daniel Kaufmann,Daniel Kaufmann,I-Cheng Ho,I-Cheng Ho +11 more
TL;DR: It is reported that the transcription factor Ets-1 is required for maintaining the expression of CD127 in murine peripheral T cells, and its absence leads to reduced CD127 expression, attenuatedIL-7 signaling, and impaired IL-7–dependent homeostatic proliferation of T cells.