William Apruzzese

TL;DR: Several single-cell -omics approaches are used to define the cellular processes and pathways in the human RA joint and attributed IL6 expression to THY1+HLA-DRAhi fibroblasts and IL1B production to pro-inflammatory monocytes, potentially key mediators of RA pathogenesis.

TL;DR: Analysis of kidney samples from patients with lupus nephritis and healthy control subjects revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses.

TL;DR: Using bulk and single-cell data, inflammatory mediators to source cell populations are mapped, for example attributing IL6 production to THY1+HLAhigh fibroblasts and naïve B cells, and IL1B to pro-inflammatory monocytes, which are potentially key mediators of RA pathogenesis.

TL;DR: Urine proteomics can capture the complex biology of the kidney in lupus nephritis and patient-specific pathways may be noninvasively tracked in the urine in real time, enabling diagnosis and personalized treatment.

TL;DR: This comprehensive RA synovial atlas and molecular, tissue-based CTAP stratification reveal new insights into RA pathology and heterogeneity, which could lead to novel targeted-treatment approaches in RA.