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Yanyan Liu
Researcher at Brigham and Women's Hospital
Publications - 14
Citations - 1329
Yanyan Liu is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Lupus nephritis & Amyloid precursor protein. The author has an hindex of 9, co-authored 11 publications receiving 860 citations. Previous affiliations of Yanyan Liu include Harvard University & Purdue University.
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Journal ArticleDOI
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao,Michael F. Gurish,Jennifer L. Marshall,Kamil Slowikowski,Chamith Y. Fonseka,Yanyan Liu,Laura T. Donlin,Lauren A. Henderson,Kevin Wei,Fumitaka Mizoguchi,Nikola Teslovich,Nikola Teslovich,Michael E. Weinblatt,Elena Massarotti,Jonathan S. Coblyn,Simon M. Helfgott,Yvonne C. Lee,Derrick J. Todd,Vivian P. Bykerk,Susan M. Goodman,Susan M. Goodman,Alessandra B. Pernis,Lionel B. Ivashkiv,Elizabeth W. Karlson,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,James A. Lederer,Soumya Raychaudhuri,Michael B. Brenner +30 more
TL;DR: Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined.
Journal ArticleDOI
The immune cell landscape in kidneys of patients with lupus nephritis
Arnon Arazi,Deepak A. Rao,Celine C. Berthier,Anne Davidson,Yanyan Liu,Paul Hoover,Adam Chicoine,Thomas Eisenhaure,A. Helena Jonsson,Shuqiang Li,David J. Lieb,Fan Zhang,Kamil Slowikowski,Edward P. Browne,Akiko Noma,Danielle Sutherby,Scott Steelman,Dawn E. Smilek,Patti Tosta,William Apruzzese,Elena Massarotti,Maria Dall'Era,Meyeon Park,Diane L. Kamen,Richard A. Furie,Fernanda Payan-Schober,William F. Pendergraft,Elizabeth A. McInnis,Jill P. Buyon,Michelle Petri,Chaim Putterman,Kenneth C. Kalunian,E. Steve Woodle,James A. Lederer,David A. Hildeman,David A. Hildeman,Chad Nusbaum,Soumya Raychaudhuri,Matthias Kretzler,Jennifer H. Anolik,Michael B. Brenner,David Wofsy,Nir Hacohen,Betty Diamond +43 more
TL;DR: Analysis of kidney samples from patients with lupus nephritis and healthy control subjects revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses.
Journal ArticleDOI
Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.
Vivek Venkataramani,Thorsten R. Doeppner,Desiree Willkommen,Catherine M. Cahill,Yongjuan Xin,Yongjuan Xin,Guilin Ye,Guilin Ye,Yanyan Liu,Adam Southon,Allegra T. Aron,Ho Yu Au-Yeung,Xudong Huang,Debomoy K. Lahiri,Fudi Wang,Fudi Wang,Ashley I. Bush,Gerald Wulf,Philipp Ströbel,Bernhard Michalke,Jack T. Rogers +20 more
TL;DR: In this article, the authors demonstrate that Mn dose and time-dependently blocks the protein translation of amyloid precursor protein (APP) and heavy-chain Ferritin (H-Ferritin), both iron homeostatic proteins with neuroprotective features.
Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin
Vivek Venkataramani,Thorsten R. Doeppner,Desiree Willkommen,Catherine M. Cahill,Yongjuan Xin,Guilin Ye,Yanyan Liu,Adam Southon,Allegra T. Aron,Ho Yu Au-Yeung,Xudong Huang,Debomoy K. Lahiri,Fudi Wang,Ashley I. Bush,Gerald Wulf,Philipp Ströbel,Bernhard Michalke,Jack T. Rogers +17 more
TL;DR: The results suggest that Mn‐induced neurotoxicity is partly attributable to the translational inhibition of APP and H‐Ferritin resulting in impaired iron metabolism and exacerbated neurotoxic oxidative stress.
Journal ArticleDOI
A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity.
Jack T. Rogers,Vivek Venkataramani,Cecilia Washburn,Yanyan Liu,Vinusha Tummala,Hong Jiang,Ann Smith,Catherine M. Cahill +7 more
TL;DR: Overall, the data support a model of neurotoxicity where Pb enhances iron regulatory protein/IRE‐mediated repression of APP and FTH translation, and propose novel treatment options for Pb poisoning to include chelators and the use of small molecules to maintain APP andFTH translation.