A
Akira Iinishi
Researcher at Northeastern University
Publications - 6
Citations - 406
Akira Iinishi is an academic researcher from Northeastern University. The author has contributed to research in topics: Antibiotics & Medicine. The author has an hindex of 2, co-authored 4 publications receiving 175 citations.
Papers
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Journal ArticleDOI
A new antibiotic selectively kills Gram-negative pathogens
Yu Imai,Kirsten J. Meyer,Akira Iinishi,Quentin Favre-Godal,Robert Green,Sylvie Manuse,Mariaelena Caboni,Miho Mori,Samantha Niles,Meghan Ghiglieri,Chandrashekhar Honrao,Xiaoyu Ma,Jason J. Guo,Alexandros Makriyannis,Luis Linares-Otoya,Nils Böhringer,Zerlina G. Wuisan,Hundeep Kaur,Runrun Wu,André Mateus,Athanasios Typas,Mikhail M. Savitski,Josh L. Espinoza,Aubrie O'Rourke,Karen E. Nelson,Sebastian Hiller,Nicholas Noinaj,Till F. Schäberle,Till F. Schäberle,Anthony D'Onofrio,Kim Lewis +30 more
TL;DR: Bacterial symbionts of animals may contain antibiotics that are particularly suitable for development into therapeutics; one such compound, darobactin, is active against important Gram-negative pathogens both in vitro and in animal models of infection.
Journal ArticleDOI
A selective antibiotic for Lyme disease.
Nadja Leimer,Xiaoqian Wu,Yu Imai,Madeleine Morrissette,Norman Pitt,Quentin Favre-Godal,Akira Iinishi,Samta Jain,Mariaelena Caboni,Inga V. Leus,Vincent Bonifay,Samantha Niles,Rachel Bargabos,Meghan Ghiglieri,Rachel Corsetti,Megan Krumpoch,Gabriel Fox,Sangkeun Son,Dorota Klepacki,Yury S. Polikanov,Cecily A. Freliech,Julie E. McCarthy,Diane G. Edmondson,Steven J. Norris,Anthony D'Onofrio,Linden T. Hu,Helen I. Zgurskaya,Kim Lewis +27 more
TL;DR: Hygromycin A, a known antimicrobial produced by Streptomyces hygroscopicus, has been found to be highly selective against Borreliella burgdorferi as discussed by the authors.
Journal ArticleDOI
Computational identification of a systemic antibiotic for Gram-negative bacteria
Ryan D. Miller,Akira Iinishi,Seyed Majed Modaresi,Byung-Kuk Yoo,Thomas Curtis,Patrick J. LaRiviere,Libang Liang,Sang Hyuk Son,Samantha Nicolau,Rachel Bargabos,Madeleine Morrissette,Michael F Gates,Norman Pitt,Roman P. Jakob,Parthasarathi Rath,Timm Maier,Andrey G. Malyutin,Jens T. Kaiser,Samantha Niles,Blake Karavas,Meghan Ghiglieri,Sarah E. J. Bowman,Douglas C. Rees,Sebastian Hiller,Kim Lewis +24 more
TL;DR: In this article , a computational search for genes only distantly related to the darobactin operon may lead to novel compounds, such as Dynobactins A, a peptide antibiotic from Photorhabdus australis containing two unlinked rings.
Journal ArticleDOI
Author Correction: A new antibiotic selectively kills Gram-negative pathogens.
Yu Imai,Kirsten J. Meyer,Akira Iinishi,Quentin Favre-Godal,Robert Green,Sylvie Manuse,Mariaelena Caboni,Miho Mori,Samantha Niles,Meghan Ghiglieri,Chandrashekhar Honrao,Xiaoyu Ma,Jason J. Guo,Alexandros Makriyannis,Luis Linares-Otoya,Nils Böhringer,Zerlina G. Wuisan,Hundeep Kaur,Runrun Wu,André Mateus,Athanasios Typas,Mikhail M. Savitski,Josh L. Espinoza,Aubrie O'Rourke,Karen E. Nelson,Sebastian Hiller,Nicholas Noinaj,Till F. Schäberle,Till F. Schäberle,Anthony D'Onofrio,Kim Lewis +30 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Patent
Compounds with Antimicrobial Properties
TL;DR: In this paper, a novel compound of Formula (I) or stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, for use in treatment of infection caused by Gram-negative bacteria was presented.