T
Till F. Schäberle
Researcher at Fraunhofer Society
Publications - 101
Citations - 4089
Till F. Schäberle is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 24, co-authored 82 publications receiving 3154 citations. Previous affiliations of Till F. Schäberle include University of Bonn & University of Giessen.
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Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal ArticleDOI
A new antibiotic selectively kills Gram-negative pathogens
Yu Imai,Kirsten J. Meyer,Akira Iinishi,Quentin Favre-Godal,Robert Green,Sylvie Manuse,Mariaelena Caboni,Miho Mori,Samantha Niles,Meghan Ghiglieri,Chandrashekhar Honrao,Xiaoyu Ma,Jason J. Guo,Alexandros Makriyannis,Luis Linares-Otoya,Nils Böhringer,Zerlina G. Wuisan,Hundeep Kaur,Runrun Wu,André Mateus,Athanasios Typas,Mikhail M. Savitski,Josh L. Espinoza,Aubrie O'Rourke,Karen E. Nelson,Sebastian Hiller,Nicholas Noinaj,Till F. Schäberle,Till F. Schäberle,Anthony D'Onofrio,Kim Lewis +30 more
TL;DR: Bacterial symbionts of animals may contain antibiotics that are particularly suitable for development into therapeutics; one such compound, darobactin, is active against important Gram-negative pathogens both in vitro and in animal models of infection.
Journal ArticleDOI
Overcoming the current deadlock in antibiotic research
Till F. Schäberle,Ingrid M. Hack +1 more
TL;DR: To finance urgently needed incentives for antibiotic research, creative financing solutions are needed and public-private partnerships (PPPs) are a successful model for moving forward.
Journal ArticleDOI
Biosynthesis of the myxobacterial antibiotic corallopyronin A.
Özlem Erol,Till F. Schäberle,Alexander Schmitz,Shwan Rachid,Cristian Gurgui,Mustafa El Omari,Friederike Lohr,Stefan Kehraus,Jörn Piel,Rolf Müller,Gabriele M. König +10 more
TL;DR: The stereochemistry of corallopyronin A was deduced by a combination of a modified Mosher's method and ozonolysis with subsequent chiral GC analyses, and it was suggested that CorB is a trans‐acting ketosynthase and it is proposed that it catalyses the Claisen condensation responsible for the interconnection of the two chains.
Journal ArticleDOI
Antibiotics from myxobacteria
TL;DR: The review provides an overview of the potential of specific compounds, suitable for future investigations and possible clinical applications, and points out their particularities and, if known, their mode of action.