Meghan Ghiglieri

TL;DR: Bacterial symbionts of animals may contain antibiotics that are particularly suitable for development into therapeutics; one such compound, darobactin, is active against important Gram-negative pathogens both in vitro and in animal models of infection.

TL;DR: Testing cranberry extracts and whole cranberry powder on a human gut microbiome-derived community in a gut simulator found that cranberry components broadly modulate the microbiota by reducing the abundance of Enterobacteriaceae and increasing the abundanceof Bacteroidaceae.

TL;DR: Hygromycin A, a known antimicrobial produced by Streptomyces hygroscopicus, has been found to be highly selective against Borreliella burgdorferi as discussed by the authors.

TL;DR: This work screens extracts from previously uncultured soil microbes for specific activity against Mycobacterium tuberculosis, identifying three novel compounds and defines the mechanism of action of one compound, amycobactin, and demonstrates that it inhibits protein secretion through the Sec translocation machinery.

TL;DR: In this paper , a novel antimicrobial from Photorhabdus noenieputensis, which was named evybactin, was shown to be a potent and selective antibiotic acting against M. tuberculosis.