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Alan P. Kozikowski
Researcher at University of Illinois at Chicago
Publications - 198
Citations - 11235
Alan P. Kozikowski is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Nicotinic agonist & Cancer. The author has an hindex of 55, co-authored 198 publications receiving 9996 citations. Previous affiliations of Alan P. Kozikowski include University of Chicago & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.
Kyle V. Butler,Jay H. Kalin,Camille Brochier,Guilio Vistoli,Brett Langley,Alan P. Kozikowski +5 more
TL;DR: Tubastatin A, a hydroxamate-containing HDAC6-selective compound, displayed no neuronal toxicity, thus, forecasting the potential application of this agent and its analogues to neurodegenerative conditions.
Journal ArticleDOI
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease
Constantin d’Ydewalle,J. Krishnan,Driss Chiheb,Philip Van Damme,Joy Irobi,Alan P. Kozikowski,Pieter Vanden Berghe,Vincent Timmerman,Wim Robberecht,Ludo Van Den Bosch +9 more
TL;DR: An increase of α-tubulin acetylation induced by pharmacological inhibition of histone deacetylase 6 (HDAC6) corrected the axonal transport defects caused by HSPB1 mutations and rescued the CMT phenotype of symptomatic mutant H SPB1 mice.
Journal ArticleDOI
HDAC6 is a target for protection and regeneration following injury in the nervous system
Mark A. Rivieccio,Camille Brochier,Dianna E. Willis,Breset A. Walker,Melissa A. D'Annibale,Kathryn McLaughlin,Ambreena Siddiq,Alan P. Kozikowski,Samie R. Jaffrey,Jeffery L. Twiss,Rajiv R. Ratan,Brett Langley +11 more
TL;DR: It is shown that pan-HDAC inhibition not only promotes neuronal protection against oxidative stress, a common mediator of injury in many neurological conditions, but also promotes neurite growth on myelin-associated glycoprotein and chondroitin sulfate proteoglycan substrates.
Journal ArticleDOI
A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer.
Kevin P. Maresca,Shawn Hillier,Frank J. Femia,D. Keith,C. Barone,John Joyal,Craig Zimmerman,Alan P. Kozikowski,John A. Barrett,William C. Eckelman,John W. Babich +10 more
TL;DR: Two lead iodine compounds were radiolabeled with (123)I and (131)Iand demonstrated specific PSMA binding on human prostate cancer cells, warranting evaluation as radioligands for the detection, staging, and monitoring of prostate cancer.
Journal ArticleDOI
Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer
Catherine A. Foss,Ronnie C. Mease,Hong Fan,Yuchuan Wang,Hayden T. Ravert,Robert F. Dannals,Rafal T. Olszewski,Warren D. W. Heston,Alan P. Kozikowski,Martin G. Pomper +9 more
TL;DR: The results show the feasibility of imaging PSMA-positive prostate cancer using low molecular weight agents, including radiolabeled urea derivatives.