Alberto Ardura-Fabregat

TL;DR: It is established that graft-derived macrophages acquire, over time, microglia characteristics, including ramified morphology, longevity, radio-resistance and clonal expansion, however, even after prolonged CNS residence, transcriptomes and chromatin accessibility landscapes of engrafted, BM-derived Macrophages remain distinct from yolk sac-derived host microglial.

TL;DR: It is reported that TGFα and VEGF-B produced by microglia regulate the pathogenic activities of astrocytes in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis, and this pathway may guide new therapies for multiple sclerosis and other neurological disorders.

TL;DR: The dynamic yet discrete self-organization of mature microglia in the healthy and diseased CNS is unravels and a new multicolor fluorescence fate mapping system is established to monitor microglial dynamics during steady state and disease.

TL;DR: It is established that these cells acquire over time microglia characteristics, including ramified morphology, longevity, radio-resistance and clonal expansion, which highlight the molecular and functional heterogeneity of parenchymal brain macrophages and highlight potential clinical implications for patients treated by HSC gene therapy.

TL;DR: In this article , aortic valve calcification was evaluated using multi-slice computed tomography (MSCT) and 3mensio™ software prior to the TAVR.