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Emily C. Tjon
Researcher at Brigham and Women's Hospital
Publications - 21
Citations - 3715
Emily C. Tjon is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Immune system. The author has an hindex of 13, co-authored 18 publications receiving 2189 citations. Previous affiliations of Emily C. Tjon include Harvard University & University of Erlangen-Nuremberg.
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Journal ArticleDOI
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more
TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.
Journal ArticleDOI
Microglial control of astrocytes in response to microbial metabolites
Veit Rothhammer,Davis M. Borucki,Emily C. Tjon,Maisa C. Takenaka,Chun-Cheih Chao,Alberto Ardura-Fabregat,Kalil Alves de Lima,Cristina Gutiérrez-Vázquez,Patrick Hewson,Ori Staszewski,Manon Blain,Luke M. Healy,Tradite Neziraj,Matilde Borio,Michael A. Wheeler,Loic Lionel Dragin,David Laplaud,Jack P. Antel,Jorge I. Alvarez,Marco Prinz,Francisco J. Quintana,Francisco J. Quintana +21 more
TL;DR: It is reported that TGFα and VEGF-B produced by microglia regulate the pathogenic activities of astrocytes in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis, and this pathway may guide new therapies for multiple sclerosis and other neurological disorders.
Journal ArticleDOI
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
Maisa C. Takenaka,Galina Gabriely,Veit Rothhammer,Ivan D. Mascanfroni,Michael A. Wheeler,Chun-Cheih Chao,Cristina Gutiérrez-Vázquez,Jessica E. Kenison,Emily C. Tjon,Andreia Barroso,Tyler Vandeventer,Kalil Alves de Lima,Sonja Rothweiler,Lior Mayo,Soufiene Ghannam,Stephanie Zandee,Luke M. Healy,David H. Sherr,Mauricio F. Farez,Alexandre Prat,Jack P. Antel,David A. Reardon,Hailei Zhang,Simon C. Robson,Gad Getz,Howard L. Weiner,Francisco J. Quintana,Francisco J. Quintana +27 more
TL;DR: Using animal models and clinical samples, the authors report that glioblastoma metabolites activate the transcription factor aryl hydrocarbon receptor in tumor-associated macrophages to modulate their function and T cell immunity, promoting tumor growth.
Journal ArticleDOI
MAFG-driven astrocytes promote CNS inflammation.
Michael A. Wheeler,Iain C. Clark,Emily C. Tjon,Zhaorong Li,Stephanie Zandee,Charles P. Couturier,Brianna R. Watson,Brianna R. Watson,Giulia Scalisi,Sarah Alkwai,Sarah Alkwai,Veit Rothhammer,Assaf Rotem,John A. Heyman,Shravan Thaploo,Liliana Maria Sanmarco,Jiannis Ragoussis,David A. Weitz,Kevin Petrecca,Jeffrey R. Moffitt,Jeffrey R. Moffitt,Burkhard Becher,Jack P. Antel,Alexandre Prat,Francisco J. Quintana,Francisco J. Quintana +25 more
TL;DR: Astrocytes in EAE and multiple sclerosis were identified that were characterized by decreased expression of NRF2 and increased expression of MAFG, which cooperates with MAT2α to promote DNA methylation and represses antioxidant and anti-inflammatory transcriptional programs.
Journal ArticleDOI
A probiotic modulates the microbiome and immunity in multiple sclerosis.
Stephanie Tankou,Keren Regev,Brian C. Healy,Emily C. Tjon,Luca Laghi,Laura M. Cox,Pia Kivisäkk,Isabelle V. Pierre,Lokhande Hrishikesh,Roopali Gandhi,Sandra Cook,Bonnie I. Glanz,James Stankiewicz,Howard L. Weiner +13 more
TL;DR: Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis patients is studied.