Alberto Pessia

TL;DR: In this article, the authors report whole-genome sequencing of 3,085 pneumococcal carriage isolates from a 2.4km(2) refugee camp, which provides unprecedented resolution of the process of recombination and its impact on population evolution.

TL;DR: The evidence suggests that chronic upregulation of anabolic pathways contributes to MM progression, long-term induction of ISRmt is not protective for muscle, and rapamycin treatment trials should be considered for adult-type MM with raised FGF21.

TL;DR: It is reported that microbes can bolster or suppress the effects of fluoropyrimidines through metabolic drug interconversion involving bacterial vitamin B6, B9, and ribonucleotide metabolism, which contributes to drug efficacy.

TL;DR: The evidence indicates that blood analysis is useful in identifying NAD+ deficiency and points niacin to be an efficient NAD+ booster for treating mitochondrial myopathy.

TL;DR: It was shown that linear regression approaches, when considering chemical fingerprints as predictors, have the potential to achieve high accuracy of predicting the sensitivity of drug combinations and are freely available in DrugComb.