mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression
Nahid Akhtar Khan,Joni Nikkanen,Shuichi Yatsuga,Shuichi Yatsuga,Christopher B. Jackson,Liya Wang,Swagat Pradhan,Riikka Kivelä,Alberto Pessia,Vidya Velagapudi,Anu Suomalainen +10 more
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TLDR
The evidence suggests that chronic upregulation of anabolic pathways contributes to MM progression, long-term induction of ISRmt is not protective for muscle, and rapamycin treatment trials should be considered for adult-type MM with raised FGF21.About:
This article is published in Cell Metabolism.The article was published on 2017-08-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Mitochondrial unfolded protein response & Mitochondrial biogenesis.read more
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Cancer metabolism: looking forward
TL;DR: In this article, the authors highlight the main themes that are currently under investigation in the context of in vivo tumour metabolism, specifically emphasizing questions that remain unanswered and highlight the new interest in exploiting cancer genetic analysis for patient stratification and dietary interventions in combination with therapies that target metabolism.
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UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication
Andrew Melber,Cole M. Haynes +1 more
TL;DR: Recent findings underlying UPRmt signal transduction are discussed and how this adaptive transcriptional response may interact with other mitochondrial stress response pathways.
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Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism.
Anusha Angajala,Sangbin Lim,Joshua B. Phillips,Jin-Hwan Kim,Clayton Yates,Zongbing You,Ming Tan +6 more
TL;DR: It is demonstrated how mitochondria coordinate to alter immune responses and how changes in mitochondrial machinery contribute to alterations in immune responses.
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The role of mitochondria in aging
TL;DR: The role of mitochondria in regulating the innate immune system, the mechanisms linking mitochondrial quality control to age-dependent pathology, and the possibility that mitochondrial-to-nuclear signaling might regulate the rate of aging are discussed.
Journal ArticleDOI
Mitochondrial Diseases: Hope for the Future
TL;DR: This review focuses on the latest advances in the development of treatments for mitochondrial disease, both small molecules and gene therapies, as well as methods to prevent transmission of mitochondrial disease through the germline.
References
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
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mTOR Signaling in Growth, Metabolism, and Disease.
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR signaling network contributes to human disease is highlighted.
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Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma,John Blenis +1 more
TL;DR: Recent findings on the regulators and effectors of mTOR are highlighted and specific cases that serve as paradigms for the different modes of m TOR regulation and its control of translation are discussed.
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MetaboAnalyst: a web server for metabolomic data analysis and interpretation
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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.
TL;DR: It is proposed that RAFT1 is the direct target of FKBP12-rapamycin and a mammalian homolog of the TOR proteins, which were originally identified by mutations that confer rapamycin resistance in yeast.
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