M
Michael C. Leopold
Researcher at University of Richmond
Publications - 54
Citations - 2776
Michael C. Leopold is an academic researcher from University of Richmond. The author has contributed to research in topics: Nanoparticle & Monolayer. The author has an hindex of 21, co-authored 51 publications receiving 2580 citations. Previous affiliations of Michael C. Leopold include University of North Carolina at Chapel Hill & North Carolina State University.
Papers
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Journal ArticleDOI
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity CORRELATION WITH CELL-FREE HYDROGEN PEROXIDE PRODUCTION AND METAL REDUCTION
Xudong Huang,Math P. Cuajungco,Craig S. Atwood,Mariana A. Hartshorn,Joel D. A. Tyndall,Graeme R. Hanson,Karen C. Stokes,Michael C. Leopold,Gerd Multhaup,Lee E. Goldstein,Richard C. Scarpa,Aleister J. Saunders,James Lim,Robert D. Moir,Charles G. Glabe,Edmond F. Bowden,Colin L. Masters,David P. Fairlie,Rudolph E. Tanzi,Ashley I. Bush +19 more
TL;DR: It is reported that Cu(II) markedly potentiates the neurotoxicity exhibited by Abeta in cell culture, suggesting that certain redox active metal ions may be important in exacerbating and perhaps facilitating Abeta-mediated oxidative damage in Alzheimer's disease.
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Electron hopping conductivity and vapor sensing properties of flexible network polymer films of metal nanoparticles.
Francis P. Zamborini,Michael C. Leopold,Jocelyn F. Hicks,Pawel J. Kulesza,Marcin A. Malik,Royce W. Murray +5 more
TL;DR: Electronic conductivity results concur with the behavior of UV-vis surface plasmon adsorption bands, which are enhanced for short nonlinker ligands and when the films are dry, and the linker chains appear to have sufficient flexibility to collapse and fold with varied degrees of film swelling or dryness.
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Evaluating engineered nanoparticles in natural waters
TL;DR: In this article, the authors review characterization techniques that are used for identifying different types of ENP, and then, by extrapolation from isolation techniques appropriate for extracting ENPs from water, suggest approaches to analyze them in a variety of waters.
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3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction†
Lee E. Goldstein,Michael C. Leopold,Xudong Huang,Craig S. Atwood,Aleister J. Saunders,Mariana A. Hartshorn,James Lim,Kyle Y. Fagét,Julien Muffat,Richard C. Scarpa,Leo T. Chylack,Edmond F. Bowden,Rudolph E. Tanzi,Ashley I. Bush +13 more
TL;DR: The reaction of kynurenine pathway catabolites with copper and iron, as well as interactions with the major lenticular structural proteins, the alpha-crystallins, support the possibility that 3HK and 3HAA may be cofactors in the oxidative damage of proteins through interactions with redox-active metals and especially copper.
Journal ArticleDOI
Influence of Gold Substrate Topography on the Voltammetry of Cytochrome c Adsorbed on Carboxylic Acid Terminated Self-Assembled Monolayers
TL;DR: In this article, the influence of gold topography in the cyt c/COOH SAM/gold system was explored using probe microscopy techniques, showing that as the topography of the gold became smoother, SAMs exhibited an increased ability to block a solution probe molecule, indicative of a lower level of defectiveness.