Aleksandra Jurek

TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.

TL;DR: A probabilistic framework is presented that integrates single-cell and bulk spatial transcriptomics in order to spatially map cell types onto their respective tissues and applies to the developing human heart and mouse brain to demonstrate the power of the technique.

TL;DR: A molecular atlas is established to formally define the spatial organization of brain regions, including the molecular code for mapping and targeting of discrete neuroanatomical domains, and provides a resource for annotating the brain using a minimal gene set—a brain palette.

TL;DR: A new molecular atlas is established to formally define the identity of brain regions, and a molecular code for mapping and targeting of discrete neuroanatomical domains is established.

TL;DR: A rich resource of spatially differentially expressed genes may contribute to understanding AD pathology and identify Bok, implicated in mitochondrial physiology and cell death, as a spatially downregulated gene in the hippocampus of mouse and human AD brains.